CAJ | 학술논문

以对异丙基苯甲酸为原料经酯化、还原、氧化反应合成了对异丙基苯甲醛。其中催化剂DMF加快了酯化反应速率，质子缓释剂乙醇的加入使得还原产率提高了34.5％，当以浓硫酸为质子缓释剂时，对异丙基苯甲酸可被直接还原为醇，氧化剂KMnO4-CuSO4?5H2 O以KMnO4含量为50％最佳。合成方法相对安全环保，产品纯度达到了98.6％，总产率达到了73.8％（以对异丙基苯甲酸计）。目标化合物和中间产物通过1 H NMR表征。
이대이병기분갑산위원료경지화、환원、양화반응합성료대이병기분갑철。기중최화제DMF가쾌료지화반응속솔，질자완석제을순적가입사득환원산솔제고료34.5％，당이농류산위질자완석제시，대이병기분갑산가피직접환원위순，양화제KMnO4-CuSO4?5H2 O이KMnO4함량위50％최가。합성방법상대안전배보，산품순도체도료98.6％，총산솔체도료73.8％（이대이병기분갑산계）。목표화합물화중간산물통과1 H NMR표정。
4-Isopropylbenzaldehyde was synthesized by using 4-isopropylbenzoic acid as the starting material through esterification , reduction and oxidation.In this paper,the rate of esterification was accelerated by adding DMF ,the yield of reduction was increased by 34.5%via adding ethanol and 4-isopropylbenzoic acid could be directly reduced to the alcohol by using concentrated sulfuric acid as the proton release agent ,the best content of KMnO 4 in oxidant was 50%.Synthetic route was safe and environmental.The purity of object product was 98.6%,and the total yield reached 73.8%(calculated based on 4-isopropylbenzoic acid).All struc-tures were characterized by 1 H NMR.