CAJ | 학술논문

目的：调查门诊2型糖尿病患者单纯口服降糖药物治疗现状，并分析影响糖化血红蛋白（HbA1c）达标的可能因素。方法贵阳市三甲医院门诊收集388例符合入选标准的2型糖尿病患者，通过问卷调查收集相关资料，进行统计学分析。结果（1）388例患者中口服降糖药使用比例依次为双胍类、磺脲类、糖苷酶抑制剂及其它。治疗方案中单药治疗占48．7％，联合用药占51．3％。HbA1c＜7．0％的达标率为44．8％。（2）HbA1c达标组与未达标组患者在年龄分布、性别、有无冠心病、糖尿病家族史、口服降糖药物种类等方面无差异（P＞0．05），而在BMI、病程长短、低密度脂蛋白胆固醇、甘油三酯、就诊前1个月内发生低血糖事件次数及每天活动量等方面有明显差异（P＜0．05）。结论（1）贵阳地区三甲医院门诊2型糖尿病患者血糖控制达标率（HbA1c＜7．0％）目前处于国内调查的平均水平。（2）为求糖化血红蛋白达标应该注意BMI、病程长短、低密度脂蛋白胆固醇、甘油三酯、就诊前1个月内发生低血糖事件次数及每天活动量等相关影响因素的控制。
목적：조사문진2형당뇨병환자단순구복강당약물치료현상，병분석영향당화혈홍단백（HbA1c）체표적가능인소。방법귀양시삼갑의원문진수집388례부합입선표준적2형당뇨병환자，통과문권조사수집상관자료，진행통계학분석。결과（1）388례환자중구복강당약사용비례의차위쌍고류、광뇨류、당감매억제제급기타。치료방안중단약치료점48．7％，연합용약점51．3％。HbA1c＜7．0％적체표솔위44．8％。（2）HbA1c체표조여미체표조환자재년령분포、성별、유무관심병、당뇨병가족사、구복강당약물충류등방면무차이（P＞0．05），이재BMI、병정장단、저밀도지단백담고순、감유삼지、취진전1개월내발생저혈당사건차수급매천활동량등방면유명현차이（P＜0．05）。결론（1）귀양지구삼갑의원문진2형당뇨병환자혈당공제체표솔（HbA1c＜7．0％）목전처우국내조사적평균수평。（2）위구당화혈홍단백체표응해주의BMI、병정장단、저밀도지단백담고순、감유삼지、취진전1개월내발생저혈당사건차수급매천활동량등상관영향인소적공제。
Objective To investigate the medication patterns of simple oral hypoglycemic agents in outpatient patients with type 2 diabetes and analyze the possible factors affecting glycemic control . Methods 388 patients with type 2 diabetic who met the inclusion criteria from three class hospital of Guiyang were enrolled into the study .Patients'relevant information was collected by face to face ques-tionnaire survey .Results The ordinal ratio of oral anti-diabetic drugs consumption among the patients was metformin ,sulfonylureas ,α-glucosidase inhibitors and others .For therapeutic protocols ,48 .7%of patients were undertaking the oral medication alone ,while 51 .3% of patients with combination ther-apy .There were 44 .8% of patients targeted HbA1c<7% .The patients in the well-controlled and in the inadequately-controlled diabetic groups were similar in terms of age distribution ,gender ,family history of coronary heart disease ,family history of diabetes and types of oral hypoglycemic agents (P>0 .05) ,but there were statistically significant differences among the following aspects such as BMI , duration of disease ,low-density lipoprotein ,triglycerides ,number of hypoglycemic events in a month before treatment and daily activity (P<0 .05) .Conclusion The overall glycemic control in Guiyang is in the average level of the national survey .In order to reach the overall glycemic control ,BMI ,duration of disease ,low-density lipoprotein ,triglycerides ,number of hypoglycemic events in a month before treatment and daily activity should be controlled strictly .