CAJ | 학술논문

目的：探讨首发精神分裂症患者血清细胞因子IL-2、IL-4与正常人的差异，比较分析首发精神分裂症患者经过阿立哌唑治疗前后症状改变及细胞因子IL-2、IL-4的变化。方法选择35例首发精神分裂症患者作为研究组，35例健康志愿者作为对照组，通过流式细胞学技术测定血清标本中IL-2、IL-4的水平，用PANSS量表评定精神症状。结果（1）首发精神分裂症患者IL-2、IL-4水平与正常对照组相比，差异无统计学意义（P＞0．05）。（2）首发精神分裂症患者阿立哌唑治疗后较治疗前IL-4水平降低，差异有统计学意义（P＜0．01）。（3）首发精神分裂症阳性症状患者血清IL-2、IL-4水平在治疗前均高于对照组（P＜0．05）。（4）首发精神分裂症阳性症状患者经阿立哌唑治疗前后血清IL-2、IL-4水平差异有统计学意义（ P＜0．05）。结论首发精神分裂症患者免疫功能存在异常，非典型抗精神病药物阿立哌唑具有下调IL-2、IL-4水平的作用，阳性症状亦得到改善。
목적：탐토수발정신분렬증환자혈청세포인자IL-2、IL-4여정상인적차이，비교분석수발정신분렬증환자경과아립고서치료전후증상개변급세포인자IL-2、IL-4적변화。방법선택35례수발정신분렬증환자작위연구조，35례건강지원자작위대조조，통과류식세포학기술측정혈청표본중IL-2、IL-4적수평，용PANSS량표평정정신증상。결과（1）수발정신분렬증환자IL-2、IL-4수평여정상대조조상비，차이무통계학의의（P＞0．05）。（2）수발정신분렬증환자아립고서치료후교치료전IL-4수평강저，차이유통계학의의（P＜0．01）。（3）수발정신분렬증양성증상환자혈청IL-2、IL-4수평재치료전균고우대조조（P＜0．05）。（4）수발정신분렬증양성증상환자경아립고서치료전후혈청IL-2、IL-4수평차이유통계학의의（ P＜0．05）。결론수발정신분렬증환자면역공능존재이상，비전형항정신병약물아립고서구유하조IL-2、IL-4수평적작용，양성증상역득도개선。
Objective To explore the differences of serum IL-2 ,IL-4 in the first-episode schizo-phrenia and healthy controls were explored ,and to compare the changes of symptoms before and after aripiprazole treatment and the changes of serum IL-2 ,IL-4 .Methods Serum of IL-2 ,IL-4 was exam-ined with Flow Cytometry in 35 healthy volunteers and 35 first episode patients .The symptoms of pa-tients were evaluated with Positive and Negative Syndrome Scale .Results There were no statistical sig-nificantly differents in the serum of IL-2 ,IL-4 in the first-episode schizophrenia than normal .controls (P>0 .05) .The serum levels of IL-4 was lower in patients with first-episode schizophrenia after aripi-prazole treatment (P<0 .01) .IL-2 and IL-4 levels were increased in positive symptoms of schizophre-nia patients before aripiprazole treatment (positive symptoms) than normal controls (P<0 .05) .IL-2 and IL-4 levels were different in positive symptoms of schizophrenia patients before and after aripi-prazole treatment (P<0 .05) .Conclusion The patients with schizophrenia have immune dysfunction ;Aripiprazole of antipsychotics have lowered the level of IL-2 ,IL-4 and positive symptoms also im-proved .Conclusion.