CAJ | 학술논문

目的：对类风湿关节炎（RA）患者血清可溶性髓样细胞触发受体-1、白介素-17水平进行研究。方法：选取本院2010年1月-2012年12月住院部和门诊收治的类风湿关节炎患者50例（观察组），将50例患者按照DSA28的评分大小分为活动组和非活动组，并另选取同一时间在本院进行体检的健康者50例为对照组，应用酶联免疫吸附试验法（ELISA）对所有患者的TREM-1和IL-17进行检验，并同时检测观察组患者的RHF、CRP、CCP以及C3水平。结果：观察组的TREM-1和IL-17水平明显大于对照组（P<0.05）；活动组的TREM-1水平明显大于非活动组（P<0.05），活动组和非活动组IL-17水平比较差异无统计学意义（P>0.05）。对RA患者活动组和非活动组各项血清指标的比较：CCP和RHF指标组间比较差异均无统计学意义（P>0.05）；而CRP、C3指标比较差异均有统计学意义（P<0.05）。结论：TREM-1指标在RA患者中呈高表达，TREM-1可以作为反映RA患者病情活动的重要指标，且IL-17和TREM-1之间可协同作用。
목적：대류풍습관절염（RA）환자혈청가용성수양세포촉발수체-1、백개소-17수평진행연구。방법：선취본원2010년1월-2012년12월주원부화문진수치적류풍습관절염환자50례（관찰조），장50례환자안조DSA28적평분대소분위활동조화비활동조，병령선취동일시간재본원진행체검적건강자50례위대조조，응용매련면역흡부시험법（ELISA）대소유환자적TREM-1화IL-17진행검험，병동시검측관찰조환자적RHF、CRP、CCP이급C3수평。결과：관찰조적TREM-1화IL-17수평명현대우대조조（P<0.05）；활동조적TREM-1수평명현대우비활동조（P<0.05），활동조화비활동조IL-17수평비교차이무통계학의의（P>0.05）。대RA환자활동조화비활동조각항혈청지표적비교：CCP화RHF지표조간비교차이균무통계학의의（P>0.05）；이CRP、C3지표비교차이균유통계학의의（P<0.05）。결론：TREM-1지표재RA환자중정고표체，TREM-1가이작위반영RA환자병정활동적중요지표，차IL-17화TREM-1지간가협동작용。
Objective:To study serum soluble myeloid cells trigger receptor-1 interleukin-17 level of rheumatoid arthritis patients.Method:50 patients(treatment group)with rheumatoid arthritis inpatient and outpatient were chosen from our hospital from January 2010 to December 2012. According to DSA28 ratings,50 cases were devided into active and inactive groups,at the same time 50 cases of healthy subjects were chosen in the hospital for a control group.The levels of TREM-1 and IL-17 of the four groups patients were tested by using enzyme-linked immunosorbent assay(ELISA). At the same time,the RHF,CRP,CCP and C3 level of the treatment group patients were detected.Result:The TREM-1 and IL-17 levels of the treatment group was significantly greater than that of the control group(P<0.05);the TREM-1 level of the active group was significantly greater than that of inactive group(P<0.05).There was no significant difference in CCP and RHF between the active and inactive groups in RA patients(P>0.05),but there was obvious difference of CRP and C3(P<0.05).Conclusion:The TREM-1 indexes is high in patients with RA,TREM-1 can be used as an important index of disease activity in patients with RA,and IL-17 and TREM-1 can synergy each other.