CAJ | 학술논문

背景：双相磷酸钙陶瓷是由羟基磷灰石和β-磷酸三钙两相成分构成的陶瓷，其化学组成与骨组织的无机成分相似，目前体内外研究表明双相磷酸钙陶瓷除具有良好的生物相容性、生物活性、骨传导性以外，还具有骨诱导性，因此有望成为理想的骨替代材料。然而，双相磷酸钙陶瓷骨诱导的影响因素及相关机制尚不明确。目的：综述影响双相磷酸钙陶瓷骨诱导性的因素及机制。 　　方法：应用计算机检索Ovid Medline和PubMed数据库中1985年1月至2013年1月关于双相磷酸钙陶瓷骨诱导性的文章，在标题和中以“bone graft substitutes, biphasic calcium phosphates, osteoinduction”为检索词进行检索。选择文章内容与双相磷酸钙陶瓷的骨诱导性有关者，同一领域文献则选择近期发表或发表在权威杂志的文章，最终选择34篇文献进行综述。 　　结果与结论：综合相关文献发现双相磷酸钙陶瓷的化学组成通过影响钙磷的降解和再沉积速率，进而影响其骨诱导性的发挥；同时双相磷酸钙陶瓷的物理结构通过影响骨形成相关蛋白的吸附、血管生成、组织长入、局部微环境并进一步诱发干细胞的骨向分化来影响双相磷酸钙陶瓷的骨诱导性；另外双相磷酸钙陶瓷植入动物的种属，植入部位及植入体大小也可对其骨诱导性产生影响。因此通过对双相磷酸钙陶瓷骨诱导性影响因素及相关机制的研究可为制备具有稳定骨诱导性的骨替代材料提供依据。
배경：쌍상린산개도자시유간기린회석화β-린산삼개량상성분구성적도자，기화학조성여골조직적무궤성분상사，목전체내외연구표명쌍상린산개도자제구유량호적생물상용성、생물활성、골전도성이외，환구유골유도성，인차유망성위이상적골체대재료。연이，쌍상린산개도자골유도적영향인소급상관궤제상불명학。목적：종술영향쌍상린산개도자골유도성적인소급궤제。 　　방법：응용계산궤검색Ovid Medline화PubMed수거고중1985년1월지2013년1월관우쌍상린산개도자골유도성적문장，재표제화중이“bone graft substitutes, biphasic calcium phosphates, osteoinduction”위검색사진행검색。선택문장내용여쌍상린산개도자적골유도성유관자，동일영역문헌칙선택근기발표혹발표재권위잡지적문장，최종선택34편문헌진행종술。 　　결과여결론：종합상관문헌발현쌍상린산개도자적화학조성통과영향개린적강해화재침적속솔，진이영향기골유도성적발휘；동시쌍상린산개도자적물리결구통과영향골형성상관단백적흡부、혈관생성、조직장입、국부미배경병진일보유발간세포적골향분화래영향쌍상린산개도자적골유도성；령외쌍상린산개도자식입동물적충속，식입부위급식입체대소야가대기골유도성산생영향。인차통과대쌍상린산개도자골유도성영향인소급상관궤제적연구가위제비구유은정골유도성적골체대재료제공의거。
BACKGROUND:Biphasic calcium phosphates, consisting of hydroxyapatite and beta-tricalcium phosphate, have been extensively applied as bone graft substitutes due to their similarity with the mineral portion of nature bone. They have been proved to have excellent biocompatibility, bioactivity and osteoconductivity. In recent years, many studies have il ustrated biphasic calcium phosphates perform osteoinductivity both in vitro and in vivo, which is expected to become a good choice for bone graft substitutes. However, the critical factors triggering the osteoinduction process and mechanism of this phenomenon are stil indistinct. OBJECTIVE:To review the influencing factors and mechanism related to the osteoinductivity of biphasic calcium phosphates. METHODS:The Ovid Medline database and PubMed database (1985-01/2013-01) were used to search the related articles about the osteoinductive property of biphasic calcium phosphates. The key words were“bone graft substitutes, biphasic calcium phosphates, osteoinduction”. Articles concerning the osteoinductive property of biphasic calcium phosphates were included. The articles that published recently or in the high-impact journals were preferred, and articles with repetitive contents were ruled out. Then 34 articles were suitable for further analysis. RESULTS AND CONCLUSION:The chemical composition of biphasic calcium phosphates influences the rate of degradation/resorption as wel as bioactivity, which in turn has an influence on the osteoinductivity;the physical properties also play important roles in osteoinductivity by affecting the absorption of bone morphogenetic proteins, vascularization, tissue invasion, microenvironment, and more importantly, triggering the undifferentiated stem cells into osteogenic lineage. What’s more, the species of animals, the implantation-site and the implant size are also critical for osteoinduction. Therefore, through the further study on the influencing factors and mechanism of osteoinduction, biphasic calcium phosphates with stable osteoinductivity, as a promising bone graft substitute, could be synthesized for clinical applications.