CAJ | 학술논문

背景：添加合金元素是改变镁合金微观结构和控制镁合金降解行为的有效方法。 　　目的：探讨Mg-Nd-Zn-Zr镁合金体内外的降解行为。 　　方法：①体外静态浸泡实验：在(37.0±0.5)℃条件下，将 Mg-Nd-Zn-Zr 镁合金和纯镁各6个样品分别浸入250 mL模拟体液中，浸泡过程中不搅拌振荡。静态浸泡第3，7，30天后从模拟体液中取出试样，扫描电镜及能谱分析分析Mg-Nd-Zn-Zr镁合金在模拟体液中的降解行为。②体内植入实验：在成年新西兰兔左侧股骨钻孔，实验组植入Mg-Nd-Zn-Zr镁合金，对照组植入钛合金，空白对照组不植入任何内植物。植入后1，2，4，8周，通过X射线观察内植物的位置及降解行为；植入后4，8周，通过扫描电镜观察Mg-Nd-Zn-Zr镁合金表面腐蚀产物，通过元素能谱分析腐蚀产物的成分，并计算材料降解速率。 　　结果与结论：①M g-Nd-Zn-Zr镁合金浸泡于模拟体液中不同时间点的降解速率均低于纯镁组；浸泡30 d后，沉积于Mg-Nd-Zn-Zr镁合金表面的腐蚀产物主要是氧、碳、钠、镁、钙、磷和氯，去除腐蚀产物后Mg-Nd-Zn-Zr镁合金和纯镁表面均有腐蚀坑，但Mg-Nd-Zn-Zr镁合金表面腐蚀坑体积更小，分布更均匀，表明Mg-Nd-Zn-Zr镁合金和纯镁存在不同的腐蚀形式。②M g-Nd-Zn-Zr 镁合金植入动物体内后随时间延长逐渐降解，材料表面腐蚀产物及成分类似于体外浸泡实验。
배경：첨가합금원소시개변미합금미관결구화공제미합금강해행위적유효방법。 　　목적：탐토Mg-Nd-Zn-Zr미합금체내외적강해행위。 　　방법：①체외정태침포실험：재(37.0±0.5)℃조건하，장 Mg-Nd-Zn-Zr 미합금화순미각6개양품분별침입250 mL모의체액중，침포과정중불교반진탕。정태침포제3，7，30천후종모의체액중취출시양，소묘전경급능보분석분석Mg-Nd-Zn-Zr미합금재모의체액중적강해행위。②체내식입실험：재성년신서란토좌측고골찬공，실험조식입Mg-Nd-Zn-Zr미합금，대조조식입태합금，공백대조조불식입임하내식물。식입후1，2，4，8주，통과X사선관찰내식물적위치급강해행위；식입후4，8주，통과소묘전경관찰Mg-Nd-Zn-Zr미합금표면부식산물，통과원소능보분석부식산물적성분，병계산재료강해속솔。 　　결과여결론：①M g-Nd-Zn-Zr미합금침포우모의체액중불동시간점적강해속솔균저우순미조；침포30 d후，침적우Mg-Nd-Zn-Zr미합금표면적부식산물주요시양、탄、납、미、개、린화록，거제부식산물후Mg-Nd-Zn-Zr미합금화순미표면균유부식갱，단Mg-Nd-Zn-Zr미합금표면부식갱체적경소，분포경균균，표명Mg-Nd-Zn-Zr미합금화순미존재불동적부식형식。②M g-Nd-Zn-Zr 미합금식입동물체내후수시간연장축점강해，재료표면부식산물급성분유사우체외침포실험。
BACKGROUND:Al oying is a convenient and effective method to alter the microstructure and control the corrosion behavior of magnesium al oy. OBJECTIVE:To explore the in vitro and in vivo degradation of Mg-Nd-Zn-Zr al oy as a degradable medical biomaterial. METHODS:(1) In vitro static immersion test:The immersion tests were carried out at (37.0±0.5) thermostatic bath. Six Mg-Nd-Zn-Zr al oy samples and six pure magnesium samples were immersed in the 250 mL simulated body fluid and vibrated without agitation during immersion. After 3, 7 and 30 days static immersion, the samples were taken out from the simulated body fluid. Then the in vitro corrosion properties were evaluated using scanning electron microscope and energy dispersive spectrometer analysis. (2) In vivo animal experiment:After bone tunnel was established in the left femur of adult New Zealand rabbits, the Mg-Nd-Zn-Zr al oy rods were embedded in the Mg-Nd-Zn-Zr al oy group, titanium al oy rods were embedded in the titanium al oy group, and only bone tunnel was established in the sham-operated group. At 1, 2, 4, 8 weeks after implantation, an X-ray of the implanted region was taken to determine the location and the degradation behavior℃in a of Mg-Nd-Zn-Zr al oy. At 4, 8 weeks after implantation, the corrosion product and its element composition were observed using scanning electron microscope with an energy dispersive spectroscopy system.