CAJ | 학술논문

背景：骨关节炎动物模型的建立方法多种多样，不同的造模方法、不同的造模动物选择所建立的骨关节炎模型有其各自的特点。 　　目的：综合分析骨关节炎动物模型的研究现状。 　　方法：应用计算机检索Medline 2002年1月至2012年10月有关骨关节炎动物模型的文章，检索词为“animal model, osteoarthritis”，限定语言种类为英文，同时计算机检索中国期刊全文数据库同期骨关节炎动物模型相关文章，检索词为“骨关节炎、动物模型、研究进展”，限定语言种类为中文。共收集到423篇有关骨关节炎动物模型研究的文献，128篇符合标准，查找全文阅读后纳入40篇进行综述。 　　结果与结论：人工诱导动物模型是目前骨关节炎动物模型建立的主要方法，在研究骨关节炎发病机制、药物疗效、软骨生理病理等方面应用广泛。自发性骨关节炎模型在研究原发性骨关节炎的起始机制、关节软骨生化改变和防治效果的比较等方面具有极大优势。转基因动物模型在研究软骨修复机制及测试某一基因对防止、延缓或逆转骨关节炎形态变化的作用具有广阔的研究前景。在选择模型时应根据研究需要进行综合考虑。
배경：골관절염동물모형적건립방법다충다양，불동적조모방법、불동적조모동물선택소건립적골관절염모형유기각자적특점。 　　목적：종합분석골관절염동물모형적연구현상。 　　방법：응용계산궤검색Medline 2002년1월지2012년10월유관골관절염동물모형적문장，검색사위“animal model, osteoarthritis”，한정어언충류위영문，동시계산궤검색중국기간전문수거고동기골관절염동물모형상관문장，검색사위“골관절염、동물모형、연구진전”，한정어언충류위중문。공수집도423편유관골관절염동물모형연구적문헌，128편부합표준，사조전문열독후납입40편진행종술。 　　결과여결론：인공유도동물모형시목전골관절염동물모형건립적주요방법，재연구골관절염발병궤제、약물료효、연골생리병리등방면응용엄범。자발성골관절염모형재연구원발성골관절염적기시궤제、관절연골생화개변화방치효과적비교등방면구유겁대우세。전기인동물모형재연구연골수복궤제급측시모일기인대방지、연완혹역전골관절염형태변화적작용구유엄활적연구전경。재선택모형시응근거연구수요진행종합고필。
BACKGROUND:There are a variety of methods for establishing osteoarthritis animal model, and different methods and different animals have their own characteristics. OBJECTIVE:To review the status of the research on osteoarthritis animal models. METHODS:The relevant articles to the osteoarthritis animal models were searched in Medline database from January 2002 to October 2011, with the key words of“animal model, osteoarthritis”in English by the computer. Similarly, Chinese Journal Ful-text Database was retrieved for related articles published in Chinese from January 2002 to October 2011, with the key words of“animal model, osteoarthritis, research development”in Chinese. Total y 423 relevant articles were col ected and 128 of them conformed the standard. At last 40 articles were included to review after ful-text reading. RESULTS AND CONCLUSION:The artificial induced animal models are the principal means to establish animal models of osteoarthritis and they have been widely used in the study of osteoarthritis pathogenesis, drug efficacy, cartilage physiology and pathology. Spontaneous osteoarthritis animal models have great advantages in the study addressing the initial mechanism of osteoarthritis, the biochemical changes of articular cartilage and the comparison of prevention and cure effects. Transgenic animal models have great application prospects on studying cartilage repairing mechanisms and testing a gene to prevent, delay or reversal the morphological changes. Accordingly the choice of models should be based on research needs.