CAJ | 학술논문

背景：研究发现辛伐他汀具有促进新骨形成的作用，但其成骨机制及成骨效果目前仍然存在争议。 　　目的：对比观察Bio-Oss/辛伐他汀复合材料与单纯Bio-Oss修复材料修复兔下颌骨骨缺损区的成骨效果。 　　方法：12只新西兰大白兔下颌骨双侧制备缺损，随机将一侧采用辛伐他汀复合Bio-Oss修复缺损区；另一侧采用单纯Bio-Oss修复缺损区。两组均覆盖Bio-Gide胶原膜。植骨后4，8，12周分别处死各组兔子4只，通过大体观察，X射线及口腔锥形束CT影像学观察，组织学切片观察，定性定量对比分析植骨区牙槽骨形成情况。 　　结果与结论：植骨后4，8，12周新骨形成逐渐增多，随着高阻射的Bio-Oss骨粉逐渐降解，在各时间点密度值测量结果辛伐他汀复合Bio-Oss组均显著低于单纯Bio-Oss组(P<0.05)。新生骨百分比测量结果辛伐他汀复合Bio-Oss均显著高于单纯Bio-Oss组(P<0.05)。提示辛伐他汀具有促进Bio-Oss骨粉吸收的效果，在骨缺损修复中具有促进新骨生成的作用。
배경：연구발현신벌타정구유촉진신골형성적작용，단기성골궤제급성골효과목전잉연존재쟁의。 　　목적：대비관찰Bio-Oss/신벌타정복합재료여단순Bio-Oss수복재료수복토하합골골결손구적성골효과。 　　방법：12지신서란대백토하합골쌍측제비결손，수궤장일측채용신벌타정복합Bio-Oss수복결손구；령일측채용단순Bio-Oss수복결손구。량조균복개Bio-Gide효원막。식골후4，8，12주분별처사각조토자4지，통과대체관찰，X사선급구강추형속CT영상학관찰，조직학절편관찰，정성정량대비분석식골구아조골형성정황。 　　결과여결론：식골후4，8，12주신골형성축점증다，수착고조사적Bio-Oss골분축점강해，재각시간점밀도치측량결과신벌타정복합Bio-Oss조균현저저우단순Bio-Oss조(P<0.05)。신생골백분비측량결과신벌타정복합Bio-Oss균현저고우단순Bio-Oss조(P<0.05)。제시신벌타정구유촉진Bio-Oss골분흡수적효과，재골결손수복중구유촉진신골생성적작용。
BACKGROUND:Studies have shown that simvastatin can promote bone formation, but there is stil controversial on the osteogenic mechanism and osteogenic effect. OBJECTIVE:To explore the osteogenesis effect of the composite of simvastatin and Bio-Oss versus simple Bio-Oss material on the repair of rabbit mandibular defects. METHODS:Twelve New Zealand white rabbits were selected to establish alveolar bilateral mandibular defects models. The composite of simvastatin and Bio-Oss was implanted randomly in one side of defect region;Bio-Oss was simply implanted in the other side of defect region. Both sides were covered with Bio-Gide bilayer col agen membrane. Four rabbits in each group were sacrificed at 4, 8 and 12 weeks after implantation, and the general observation X-ray film, oral cone-beam CT imaging observation and histopathologic study and quantitatively were conducted to quantitatively and qualitatively comparative analyze the alveolar bone formation in the graft region. RESULTS AND CONCLUSION:At 4, 8 and 12 weeks after implantation, new bone formation was found and increased with time prolonging. With the gradual degeneration of high resistance fire Bio-Oss bone meal, the bone mineral density at different time points of the simvastatin composite Bio-Oss group was lower than that of the simple Bio-Oss group (P<0.05). The percentage of bone formation in the simvastatin composite Bio-Oss group was significantly higher than that in the simple Bio-Oss group (P<0.05). Simvastatin could accelerate Bio-Oss degradation and promote new bone formation in bone defects repairing.