中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
8期
1055-1057
,共3页
高血压%年龄%焦虑状态%同型半胱氨酸
高血壓%年齡%焦慮狀態%同型半胱氨痠
고혈압%년령%초필상태%동형반광안산
Hypertension%Age%Anxiety%Homocysteine
目的 研究血清同型半胱氨酸(Hcy)水平及年龄因素在高血压患者合并焦虑状态之间的关系.方法 对164例近1周常规治疗血压仍不稳定的原发性高血压患者进行患者健康问卷抑郁量表(PHQ-9)和广泛性焦虑量表(GAD-7)抑郁焦虑状态测评,根据合并焦虑状态情况分为无焦虑组(28例)、轻中度焦虑组(81例)和重度焦虑组(55例).分析患者的GAD-7水平,同时检测患者Hcy、LDL-C、HDL-C、高敏C反应蛋白(hs-CRP)和纤维蛋白原(FIB),比较3组间的差别及与高血压合并焦虑状态程度的相关性.结果 无焦虑组、轻中度焦虑组、重度焦虑组的年龄分别为(58.1±2.4)、(58.2±2.0)、(60.6±2.3)岁,Hcy分别为(12.8±0.8)、(16.4±0.7)、(17.4±1.1) μmol/L,3组年龄及Hcy比较差异均有统计学意义(P＜0.05).相关分析显示GAD-7评分与PHQ-9评分相关,相关系数为0.581 (P ＜0.01)；GAD-7评分与Hcy及年龄相关；与其他检验指标未显示相关性.多元回归分析显示PHQ-9、Hcy及年龄是影响高血压合并焦虑状态评分的重要因素.结论 Hcy水平和年龄因素与高血压合并焦虑状态程度具有相关性.
目的 研究血清同型半胱氨痠(Hcy)水平及年齡因素在高血壓患者閤併焦慮狀態之間的關繫.方法 對164例近1週常規治療血壓仍不穩定的原髮性高血壓患者進行患者健康問捲抑鬱量錶(PHQ-9)和廣汎性焦慮量錶(GAD-7)抑鬱焦慮狀態測評,根據閤併焦慮狀態情況分為無焦慮組(28例)、輕中度焦慮組(81例)和重度焦慮組(55例).分析患者的GAD-7水平,同時檢測患者Hcy、LDL-C、HDL-C、高敏C反應蛋白(hs-CRP)和纖維蛋白原(FIB),比較3組間的差彆及與高血壓閤併焦慮狀態程度的相關性.結果 無焦慮組、輕中度焦慮組、重度焦慮組的年齡分彆為(58.1±2.4)、(58.2±2.0)、(60.6±2.3)歲,Hcy分彆為(12.8±0.8)、(16.4±0.7)、(17.4±1.1) μmol/L,3組年齡及Hcy比較差異均有統計學意義(P＜0.05).相關分析顯示GAD-7評分與PHQ-9評分相關,相關繫數為0.581 (P ＜0.01)；GAD-7評分與Hcy及年齡相關；與其他檢驗指標未顯示相關性.多元迴歸分析顯示PHQ-9、Hcy及年齡是影響高血壓閤併焦慮狀態評分的重要因素.結論 Hcy水平和年齡因素與高血壓閤併焦慮狀態程度具有相關性.
목적 연구혈청동형반광안산(Hcy)수평급년령인소재고혈압환자합병초필상태지간적관계.방법 대164례근1주상규치료혈압잉불은정적원발성고혈압환자진행환자건강문권억욱량표(PHQ-9)화엄범성초필량표(GAD-7)억욱초필상태측평,근거합병초필상태정황분위무초필조(28례)、경중도초필조(81례)화중도초필조(55례).분석환자적GAD-7수평,동시검측환자Hcy、LDL-C、HDL-C、고민C반응단백(hs-CRP)화섬유단백원(FIB),비교3조간적차별급여고혈압합병초필상태정도적상관성.결과 무초필조、경중도초필조、중도초필조적년령분별위(58.1±2.4)、(58.2±2.0)、(60.6±2.3)세,Hcy분별위(12.8±0.8)、(16.4±0.7)、(17.4±1.1) μmol/L,3조년령급Hcy비교차이균유통계학의의(P＜0.05).상관분석현시GAD-7평분여PHQ-9평분상관,상관계수위0.581 (P ＜0.01)；GAD-7평분여Hcy급년령상관；여기타검험지표미현시상관성.다원회귀분석현시PHQ-9、Hcy급년령시영향고혈압합병초필상태평분적중요인소.결론 Hcy수평화년령인소여고혈압합병초필상태정도구유상관성.
Objective To study the relation between serum homocysteine levels and age in patients of high blood pressure combined with anxiety state.Methods Totally 164 patients with primary hypertension were assessed in health questionnaire depression scale (PHQ-9) and generalized anxiety scale (GAD-7).According to merge anxiety,all patients were divided into no anxiety group (28 cases),mild-to-moderate anxiety group (81 cases) and severe anxiety group (55 cases).GAD-7 levels of patients were analyzed.Homocysteine,low density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol (HDL-C),high sensitive C-reactive protein and fibrinogen level of patients were detected; the differences among the three groups and the anxiety degree of correlation in combination with high blood pressure were compared.Results Mean age of no anxiety group,mild-to-moderate anxiety group and severe anxiety group was (58.1 ± 2.4),(58.2 ± 2.0),(60.6 ± 2.3) years respectively.Hcy was (12.8 ± 0.8),(16.4 ± 0.7),(17.4 ± 1.1) μmol/L respectively; there were significant differences on the age and Hcy among three groups (P ＜ 0.05).Analysis showed that GAD-7 score was associated with PHQ-9 scores ; correlation coefficient was 0.581 (P ＜ 0.01).Multiple regression analysis showed that PHQ-9,Hcy and age were the important factors that affected hypertension combined anxiety state score.Conclusion Hcy levels and age factors are associated with degree of hypertension combined anxiety state.
