中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
8期
1199-1201
,共3页
陈冬军%陈建华%殷英霞%王伟%司佳玥%赵慧英%吴香丽%刘彦%任艳霞
陳鼕軍%陳建華%慇英霞%王偉%司佳玥%趙慧英%吳香麗%劉彥%任豔霞
진동군%진건화%은영하%왕위%사가모%조혜영%오향려%류언%임염하
视神经损伤%糖尿病%乙胺丁醇%日剂量
視神經損傷%糖尿病%乙胺丁醇%日劑量
시신경손상%당뇨병%을알정순%일제량
Optic nerve injuries%Diabetes mellitus%Ethambutol%Daily dose
目的 探讨乙胺丁醇中毒性视神经病变的影响因素.方法 选取2012年1月至2013年12月北京老年医院眼科就诊患者56例,对其服用乙胺丁醇致视神经病变的各种影响因素进行回顾性分析.结果 将年龄作为控制变量,结果显示日剂量与患者服药至视功能损害时间呈负相关[日剂量分别为0.75、1.00、1.25 g,服药至视功能损害时间分别为(179±53)、(148±47)、(114±19)d,r=-0.283,P＜0.05].不同日剂量组患者就诊时视力差异有统计学意义[日剂量分别为0.75、1.00、1.25 g,就诊时视力分别为(0.61±0.25)、(0.39±0.18)、(0.27 ±0.13),F=5.762,P＜0.01].同样,控制年龄变量,等级相关分析结果显示日剂量与视野损害发生率呈正相关(r =0.871,P＜0.01),与色觉损害发生率也呈正相关(r=0.842,P＜0.01).将年龄与服药剂量作为控制变量,探讨糖尿病患者的视功能损害情况.56例患者中17例合并糖尿病,39例未合并糖尿病.合并糖尿病与未合并糖尿病患者就诊时视力差异无统计学意义[就诊时视力分别为(0.56±0.24)、(0.35±0.18),F=2.442,P＞0.05].与视野及色觉的等级相关分析结果显示,是否患糖尿病与视野损害发生率呈正相关(r =0.327,P＜0.05),与色觉损害发生率也呈正相关(r=0.605,P＜0.01).结论 乙胺丁醇日剂量高和合并糖尿病是乙胺丁醇致视神经损害的危险因素.
目的 探討乙胺丁醇中毒性視神經病變的影響因素.方法 選取2012年1月至2013年12月北京老年醫院眼科就診患者56例,對其服用乙胺丁醇緻視神經病變的各種影響因素進行迴顧性分析.結果 將年齡作為控製變量,結果顯示日劑量與患者服藥至視功能損害時間呈負相關[日劑量分彆為0.75、1.00、1.25 g,服藥至視功能損害時間分彆為(179±53)、(148±47)、(114±19)d,r=-0.283,P＜0.05].不同日劑量組患者就診時視力差異有統計學意義[日劑量分彆為0.75、1.00、1.25 g,就診時視力分彆為(0.61±0.25)、(0.39±0.18)、(0.27 ±0.13),F=5.762,P＜0.01].同樣,控製年齡變量,等級相關分析結果顯示日劑量與視野損害髮生率呈正相關(r =0.871,P＜0.01),與色覺損害髮生率也呈正相關(r=0.842,P＜0.01).將年齡與服藥劑量作為控製變量,探討糖尿病患者的視功能損害情況.56例患者中17例閤併糖尿病,39例未閤併糖尿病.閤併糖尿病與未閤併糖尿病患者就診時視力差異無統計學意義[就診時視力分彆為(0.56±0.24)、(0.35±0.18),F=2.442,P＞0.05].與視野及色覺的等級相關分析結果顯示,是否患糖尿病與視野損害髮生率呈正相關(r =0.327,P＜0.05),與色覺損害髮生率也呈正相關(r=0.605,P＜0.01).結論 乙胺丁醇日劑量高和閤併糖尿病是乙胺丁醇緻視神經損害的危險因素.
목적 탐토을알정순중독성시신경병변적영향인소.방법 선취2012년1월지2013년12월북경노년의원안과취진환자56례,대기복용을알정순치시신경병변적각충영향인소진행회고성분석.결과 장년령작위공제변량,결과현시일제량여환자복약지시공능손해시간정부상관[일제량분별위0.75、1.00、1.25 g,복약지시공능손해시간분별위(179±53)、(148±47)、(114±19)d,r=-0.283,P＜0.05].불동일제량조환자취진시시력차이유통계학의의[일제량분별위0.75、1.00、1.25 g,취진시시력분별위(0.61±0.25)、(0.39±0.18)、(0.27 ±0.13),F=5.762,P＜0.01].동양,공제년령변량,등급상관분석결과현시일제량여시야손해발생솔정정상관(r =0.871,P＜0.01),여색각손해발생솔야정정상관(r=0.842,P＜0.01).장년령여복약제량작위공제변량,탐토당뇨병환자적시공능손해정황.56례환자중17례합병당뇨병,39례미합병당뇨병.합병당뇨병여미합병당뇨병환자취진시시력차이무통계학의의[취진시시력분별위(0.56±0.24)、(0.35±0.18),F=2.442,P＞0.05].여시야급색각적등급상관분석결과현시,시부환당뇨병여시야손해발생솔정정상관(r =0.327,P＜0.05),여색각손해발생솔야정정상관(r=0.605,P＜0.01).결론 을알정순일제량고화합병당뇨병시을알정순치시신경손해적위험인소.
Objective To investigate the risk factors of optic neuropathy by ethambutol toxicity.Methods Fifty-six patients of optic neuropathy by ethambutol toxicity were analyzed to explore potential risk factors.All cases were enrolled in ophthalnology department,Beijing geriatric hospital,from January 2012 to December 2013.Results Daily dosage was significantly associated with the duration to visual impairment[daily doses were 0.75 g,1.00 g,1.25 g,the time of taking medicine to visual function damage were (179 ± 53) d,(148 ± 47) d,(114± 19) d,r =-0.283,P ＜ 0.05].Significant difference between different daily dosage groups was found regarding visual acuity [treatment of vision were (0.61 ± 0.25),(0.39 ± 0.18),(0.27 ± 0.13),F =5.762,P ＜ 0.01].After adjusted age with rank correlation analysis,daily dosage was significantly associated with the impairment of visual field (r =0.871,P ＜0.01) and color vision (r =0.842,P ＜0.01).Visual function of diabetic retinopathy patients was investigated with age and daily dosage adjusted in analysis.No difference for visual acuity was detected between the two groups [treatment of vision were (0.56 ± 0.24),(0.35 ± 0.18),F =2.442,P ＞ 0.05].Rank correlation analysis showed that diabetes was significantly associated with the impairment of visual field (r=0.327,P＜0.05) and color vision (r=0.605,P＜0.01).Conclusion High daily dose and presence of diabetes are risk factors for optic neuropathy by ethambutol toxicity.
