CAJ | 학술논문

目的评价青光眼激光周边虹膜切除术对角膜内皮的影响.方法临床病例对照研究.收集2010年1月至2011年12月在深圳市第二人民医院眼科诊断为闭角型青光眼患者125例(167只眼),由同一位医师行激光周边虹膜切开术,术前和术后1周、1个月及3个月采用角膜内皮镜检测角膜上部、中央区和下部的角膜内皮,测量角膜内皮细胞的密度、六边形细胞比率和细胞面积.结果 104例(141只眼)完成3个月的随访.术后角膜内皮细胞密度下降、六边形细胞比例下降、细胞面积扩大.角膜内皮的损伤上方最重,中部次之,下部无明显损伤.角膜上部、中央区和下部的角膜内皮细胞密度、六边形细胞比例和角膜内皮细胞面积差异在1周时差别最大,差异有统计学意义(均P＜O.01).结论激光周边虹膜切开术对角膜内皮细胞损伤小,损伤部位以角膜上部为主.激光周边虹膜切开术是闭角型青光眼一种安全有效地治疗方式.
목적 평개청광안격광주변홍막절제술대각막내피적영향.방법 림상병례대조연구.수집2010년1월지2011년12월재심수시제이인민의원안과진단위폐각형청광안환자125례(167지안),유동일위의사행격광주변홍막절개술,술전화술후1주、1개월급3개월채용각막내피경검측각막상부、중앙구화하부적각막내피,측량각막내피세포적밀도、륙변형세포비솔화세포면적.결과 104례(141지안)완성3개월적수방.술후각막내피세포밀도하강、륙변형세포비례하강、세포면적확대.각막내피적손상상방최중,중부차지,하부무명현손상.각막상부、중앙구화하부적각막내피세포밀도、륙변형세포비례화각막내피세포면적차이재1주시차별최대,차이유통계학의의(균P＜O.01).결론 격광주변홍막절개술대각막내피세포손상소,손상부위이각막상부위주.격광주변홍막절개술시폐각형청광안일충안전유효지치료방식.
Objective To investigate the effect of laser peripheral iridectomy on corneal endothelial cells.Methods One hundred and twenty-five angle-closure glaucoma patients (167 eyes) were collected from January 2010 to December 2011 in our hospital.Laser peripheral iridectomy was performed by the same physician.The corneal endothelial cells on the upper,the central and the lower part of cornea were measured using corneal endothelial microscope preoperative and 1 week,1month and 3 months postoperative.The corneal endothelial cells density,hexagonal cell ratio and cell area were calculated.Results Of 104 patients (141 eyes) completed the 3-month follow-up.Decreased corneal endothelial cell density,declined in the proportion of hexagonal cells and the expanded cell area were found after operation.The damage of corneal endothelial cells was most severe at the upper part of cornea,following the central part of cornea.The damage of corneal endothelial cells at the lower part of cornea was no statistical significance as compare to pre-operation.The differences among the upper,the central and the lower part of the corneal endothelial cells density,the hexagonal cell ratio and the cell area were the largest at 1 week after operation and were statistical significances (all P ＜0.01).Conclusions Laser peripheral iridotomy has a small amount of damage on corneal endothelial cells,and the damage position is mainly at the upper part of corneal.Laser peripheral iridotomy is a safe and effective treatment for angle-closure glaucoma.