CAJ | 학술논문

目的：探讨 A-NK 细胞治疗裸鼠舌鳞癌移植瘤的效果。方法：分离培养人 A-NK 细胞；建立舌鳞癌 Tca8113-Tb 细胞皮下移植瘤模型，随机分为2组（n ＝7）对照组裸鼠瘤旁注射生理盐水，实验组裸鼠瘤旁注射 A-NK 细胞，观察33 d 后，处死裸鼠，剥离移植瘤，称瘤重，绘制肿瘤生长曲线。结果：治疗15～33 d 时实验组肿瘤体积均小于对照组（P ＜0．05），观察33 d 后，实验组和对照组瘤重（g）分别是为0．96±0．38和3．74±1．22（P ＜0．05）。结论：A-NK 细胞在裸鼠体内具有抗肿瘤效应。
목적：탐토 A-NK 세포치료라서설린암이식류적효과。방법：분리배양인 A-NK 세포；건립설린암 Tca8113-Tb 세포피하이식류모형，수궤분위2조（n ＝7）대조조라서류방주사생리염수，실험조라서류방주사 A-NK 세포，관찰33 d 후，처사라서，박리이식류，칭류중，회제종류생장곡선。결과：치료15～33 d 시실험조종류체적균소우대조조（P ＜0．05），관찰33 d 후，실험조화대조조류중（g）분별시위0．96±0．38화3．74±1．22（P ＜0．05）。결론：A-NK 세포재라서체내구유항종류효응。
Objective:To explore the treatment effect of A-NK cells on the subcutaneously transplanted tumor of tongue squamous cell carcinoma in nude mice.Methods:Tca8113-Tb cells were subcutaneously transplanted into nude mice,14 tumor bearing mice were randomly assigned to 2 groups(n =7).The mice in control group were injected with normal saline,those in the experimental group were injected with A-NK cells.All animals were killed 33 days after tumor cell transplantation,The tumor volume and weight of the mice were measured and compared.Results:A-NK cells significantly inhibited tumor growth in nude mice in terms of the volume (P <0.05).After 15 -33 d of treatment the tumor weight(g)in the treated and control mice were 0.96 ±0.38 and 3.74 ±1.22 re-spectively(P <0.05).Conclusion:A-NK cells can inhibit the growth of Tca8113-Tb cell induced tumor in nude mice.