安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2014年
2期
189-191,192
,共4页
经颅磁刺激%脑梗死%认知功能障碍
經顱磁刺激%腦梗死%認知功能障礙
경로자자격%뇌경사%인지공능장애
Transcranial magnetic stimulation%Cerebral infarction%Cognitive impairment
目的：探讨经颅磁刺激（transcranial magnetic stimulation，TMS）治疗脑梗死患者轻度认知障碍的临床疗效。方法选取60例脑梗死具有轻度认知功能损害，但未达到痴呆的诊断标准的患者，按照国际通用随机字母表分为治疗组（使用TMS治疗）和对照组（未使用TMS治疗），比较两组患者治疗前后的MMSE评分和P300的潜伏期和波幅的变化。结果治疗组治疗后的MMSE的提高分率总有效率（80％）较对照组（43．33％）高，比较差异有统计学意义（P＜0．05）。治疗组的治疗后 P300潜伏期[（312．78±4．53）ms]与治疗前[（356．24±23．12）ms]明显缩短，治疗前后潜伏期差异有统计学意义（P＜0．05），而治疗后P300波幅[（10．65±0．87）μV]与治疗前[（10．58±1．21）μV]差异无统计学意义（P＞0．05）。对照组治疗后P300潜伏期[（367．83±23．38）ms]和波幅[（10．61±0．74）μV]与治疗前P300潜伏期[（360．18±22．17）ms]和波幅[（10．53±0．83）μV]差异均无统计学意义（P＞0．05）。结论经颅磁刺激治疗可改善脑梗死患者的轻度认知功能障碍，从而改善其生活质量，且经颅磁刺激具有疗效安全等优点，值得临床推广。
目的：探討經顱磁刺激（transcranial magnetic stimulation，TMS）治療腦梗死患者輕度認知障礙的臨床療效。方法選取60例腦梗死具有輕度認知功能損害，但未達到癡呆的診斷標準的患者，按照國際通用隨機字母錶分為治療組（使用TMS治療）和對照組（未使用TMS治療），比較兩組患者治療前後的MMSE評分和P300的潛伏期和波幅的變化。結果治療組治療後的MMSE的提高分率總有效率（80％）較對照組（43．33％）高，比較差異有統計學意義（P＜0．05）。治療組的治療後 P300潛伏期[（312．78±4．53）ms]與治療前[（356．24±23．12）ms]明顯縮短，治療前後潛伏期差異有統計學意義（P＜0．05），而治療後P300波幅[（10．65±0．87）μV]與治療前[（10．58±1．21）μV]差異無統計學意義（P＞0．05）。對照組治療後P300潛伏期[（367．83±23．38）ms]和波幅[（10．61±0．74）μV]與治療前P300潛伏期[（360．18±22．17）ms]和波幅[（10．53±0．83）μV]差異均無統計學意義（P＞0．05）。結論經顱磁刺激治療可改善腦梗死患者的輕度認知功能障礙，從而改善其生活質量，且經顱磁刺激具有療效安全等優點，值得臨床推廣。
목적：탐토경로자자격（transcranial magnetic stimulation，TMS）치료뇌경사환자경도인지장애적림상료효。방법선취60례뇌경사구유경도인지공능손해，단미체도치태적진단표준적환자，안조국제통용수궤자모표분위치료조（사용TMS치료）화대조조（미사용TMS치료），비교량조환자치료전후적MMSE평분화P300적잠복기화파폭적변화。결과치료조치료후적MMSE적제고분솔총유효솔（80％）교대조조（43．33％）고，비교차이유통계학의의（P＜0．05）。치료조적치료후 P300잠복기[（312．78±4．53）ms]여치료전[（356．24±23．12）ms]명현축단，치료전후잠복기차이유통계학의의（P＜0．05），이치료후P300파폭[（10．65±0．87）μV]여치료전[（10．58±1．21）μV]차이무통계학의의（P＞0．05）。대조조치료후P300잠복기[（367．83±23．38）ms]화파폭[（10．61±0．74）μV]여치료전P300잠복기[（360．18±22．17）ms]화파폭[（10．53±0．83）μV]차이균무통계학의의（P＞0．05）。결론경로자자격치료가개선뇌경사환자적경도인지공능장애，종이개선기생활질량，차경로자자격구유료효안전등우점，치득림상추엄。
Objective To investigate the efficacy of transcranial magnetic stimulation (TMS)treatment for cerebral infarction pa-tients with mild cognitive impairment.Methods Sixty cases of cerebral infarction patients who had mild cognitive impairment but did not meet the diagnostic criteria for dementia were enrolled and randomly divided into treatment group (using TMS therapy)and the control group (not using TMS therapy)in accordance with international common randomization form.MMSE score and P300 latency and amplitude changes were compared between the two groups before and after treatment.Results Total efficiency of MMSE improvement fraction of the two groups was calculated before and after treatment,which was higher in the study group(80%)than in the control group (43.33%),and the differ-ence was statistically significant (P<0.05).P300 latency and amplitude changes of the two groups were also compared before and after treat-ment.In the study group P300 latency was significantly shorter after treatment[(312.78 ±4.53)ms]than that before treatment[(356.24 ±23.12)ms],and the difference was statistically significant (P<0.05 ).However,P300 amplitude did not reach statically significant difference after treatment [(10.65 ±0.87)μV]compared with that before treatment [(10.58 ±1.21)μV〗(P>0.05).In the control group,P300 latency [(367.83 ±23.38)ms vs (360.18 ±22.17)ms]and amplitude [(10.65 ±0.87)μV vs (10.58 ±1.21)μV]did not reach statistically significant difference after treatment compared with that before treatment (P>0.05 ).Conclusion TMS therapy is safe and can improve the cognitive function in cerebral infarction patients with MCI,thus it improves the patients'quality of life.
