CAJ | 학술논문

[目的]探讨熟地黄多糖对阿霉素（adriamycin,doxorubicin,ADM）所致骨髓抑制及免疫功能损伤的影响。[方法]以不同剂量的熟地黄多糖灌胃正常小鼠进行预防性给药后，腹腔注射盐酸阿霉素,通过测定体重、血常规、脾指数、胸腺指数等指标,观测熟地黄多糖对阿霉素所致骨髓抑制及免疫功能损伤的影响。[结果]与模型组相比较，中药各组的小鼠体重下降程度减轻，白细胞计数、脾指数、胸腺指数均显著升高（P<0.05），其中以低、中剂量组疗效较好。[结论]熟地黄多糖对ADM所致的白细胞减少有一定的预防和保护作用，并可稳定化疗小鼠的体重及提高脾指数和胸腺指数。
[목적]탐토숙지황다당대아매소（adriamycin,doxorubicin,ADM）소치골수억제급면역공능손상적영향。[방법]이불동제량적숙지황다당관위정상소서진행예방성급약후，복강주사염산아매소,통과측정체중、혈상규、비지수、흉선지수등지표,관측숙지황다당대아매소소치골수억제급면역공능손상적영향。[결과]여모형조상비교，중약각조적소서체중하강정도감경，백세포계수、비지수、흉선지수균현저승고（P<0.05），기중이저、중제량조료효교호。[결론]숙지황다당대ADM소치적백세포감소유일정적예방화보호작용，병가은정화료소서적체중급제고비지수화흉선지수。
[Objective] To study the protective effect of polysaccharide extracted from rehmanniae preparata on adriamycin-induced myelosuppression and immunologic injury. [Methods]Use different doses of polysaccharide extracted from rehmanniae preparata,lavaging mice for preventive medicine, and then celiac inject hydrochloric adriamycin, by measuring weight,routine blood,immune function and other indicators,observing the protective effect of polysaccharide extracted from rehmanniae preparata on adriamycin-induced myelosuppression and immunologic injury. [Results]Compared with model group, medication groups of mice losing less body weight and white blood cellcount, and spleen index and thymus index al significantly increased( P<0.05),of which the intervention effect was better shown in low dose group and moderate dose group.[Conclusion]Polysaccharide extracted from rehmanniae preparata has the effect of prevention and protection on adriamycin-induced leukopenia,and it can reduce the loss of weight, spleen index and thymus index of chemotherapy mice as wel .