CAJ | 학술논문

目的：探讨应用平板运动试验评估利培酮和奥氮平对患者心功能的影响,为临床合理用药提供±据.方法选择杭州市第七人民医院2011年12月~2013年2月收治的80例服用利培酮、奥氮平进行治疗的精神分裂症患者作为研究对象,于患者服药前及服药1、2、3周后采用Bruce方案进行运动平板试验,测定其达到亚极量心率所用时间或自感筋疲力尽所需时间,并记录患者服药后不良反应情况.结果服药前及服药1周后,两组患者达到亚极量心率时间及终止试验时自我疲劳等级比较差异无统计学意义(P>0.05),而服药2周及3周后两组患者达到亚极量心率时间显著降低,利培酮组2周为(12.02±1.83)min,3周为(10.04±1.67)min,与服药前比较差异有统计学意义(P<0.05),而奥氮平组2周为(13.97±1.94)min,3周为(12.17±2.12)min,与服药前比较差异有统计学意义(P<0.05).两组终止试验时自我疲劳等级显著增高,利培酮组2周为(17.90±3.41),3周为(18.80±2.55),与服药前比较差异有统计学意义(P<0.05),而奥氮平组2周为(17.00±3.58),3周为(17.10±3.05),与服药前比较差异有统计学意义(P<0.05)；利培酮组与奥氮平组比较,差异有统计学意义(P<0.05).结论运动平板试验可有效评估利培酮和奥氮平对心血管功能的影响,尽早发现潜在的心功能障碍,指导临床合理用药。
목적：탐토응용평판운동시험평고리배동화오담평대환자심공능적영향,위림상합리용약제공±거.방법선택항주시제칠인민의원2011년12월~2013년2월수치적80례복용리배동、오담평진행치료적정신분렬증환자작위연구대상,우환자복약전급복약1、2、3주후채용Bruce방안진행운동평판시험,측정기체도아겁량심솔소용시간혹자감근피력진소수시간,병기록환자복약후불량반응정황.결과복약전급복약1주후,량조환자체도아겁량심솔시간급종지시험시자아피로등급비교차이무통계학의의(P>0.05),이복약2주급3주후량조환자체도아겁량심솔시간현저강저,리배동조2주위(12.02±1.83)min,3주위(10.04±1.67)min,여복약전비교차이유통계학의의(P<0.05),이오담평조2주위(13.97±1.94)min,3주위(12.17±2.12)min,여복약전비교차이유통계학의의(P<0.05).량조종지시험시자아피로등급현저증고,리배동조2주위(17.90±3.41),3주위(18.80±2.55),여복약전비교차이유통계학의의(P<0.05),이오담평조2주위(17.00±3.58),3주위(17.10±3.05),여복약전비교차이유통계학의의(P<0.05)；리배동조여오담평조비교,차이유통계학의의(P<0.05).결론운동평판시험가유효평고리배동화오담평대심혈관공능적영향,진조발현잠재적심공능장애,지도림상합리용약。
Objective To investigate the application of treadmill exercise test (TET) to evaluate the effects of Risperi-done and Olanzapine on cardiac function in patients, which provides the basis for the rational clinical use of antipsy-chotic drugs. Methods 80 schizophrenic patients treated in the Seventh People's Hospital of Hangzhou City from De-cember 2011 to February 2013 were chosen as the research objects. The patients took TET following the Bruce scheme before and after the treatment for 1, 2, 3 weeks, whose time of the submaximal heart rate or time of self fatigue. Be-sides, the adverse reactions of patients after taking the pills were recorded. Results Before and after the treatment 1 week, the time of submaximal heart rate and termination test self fatigue level in the two groups had no significant differences (P>0.05). But after 2 and 3 weeks, the patients achieving submaximal heart rate time reduced significantly, Rsperidone group at 2 weeks was (12.02±1.83) min, (10.04±1.67) min for 3 weeks, compared to the baseline, there was a significant difference (P<0.05), while Olanzapine group at 2 weeks was (13.97±1.94) min, (12.17±2.12) min for 3 weeks, compared to the baseline, there was a significant difference (P<0.05). Self fatigue level significantly increased, Risperi-done group at 2 weeks was (17.90±3.41), (18.80±2.55) for 3 weeks, compared to the baseline, there was a significant differ-ence (P<0.05), while Olanzapine group at 2 weeks was (17.00±3.58), (17.10±3.05) for 3 weeks, compared to the baseline, there was a significant difference (P< 0.05); compared with Olanzapine group, Risperidone group, there was a signifi cant difference (P<0.05). Conclusion TET can evaluate the affect of Risperidone and Olanzapine on cardiovascular func-tion effectively, discover the potential cardiac dysfunction as soon as possible and guide the clinical rational drug use.