中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2014年
2期
175-179
,共5页
胃肿瘤,早期%微小RNA%基因芯片
胃腫瘤,早期%微小RNA%基因芯片
위종류,조기%미소RNA%기인심편
Stomach neoplasms,early%microRNA%Gene chips
目的 检测早期胃癌组织中微小RNA(miRNA)表达谱,筛选出早期胃癌的特征性miRNA.方法 应用中通量基因芯片技术来检测5例早期胃癌组织及其癌旁组织标本中miRNA的表达.结果 相对于癌旁组织,早期胃癌组织中共有36个miRNA表达下调,如miR-9-1、miR-103、miR-141等；12个miRNA表达上调,如miR-196a、miR-142-3p、miR-25等.结论 在早期胃癌组织中表达异常的miRNA可能与胃癌发生发展有着一定的相关性.
目的 檢測早期胃癌組織中微小RNA(miRNA)錶達譜,篩選齣早期胃癌的特徵性miRNA.方法 應用中通量基因芯片技術來檢測5例早期胃癌組織及其癌徬組織標本中miRNA的錶達.結果 相對于癌徬組織,早期胃癌組織中共有36箇miRNA錶達下調,如miR-9-1、miR-103、miR-141等；12箇miRNA錶達上調,如miR-196a、miR-142-3p、miR-25等.結論 在早期胃癌組織中錶達異常的miRNA可能與胃癌髮生髮展有著一定的相關性.
목적 검측조기위암조직중미소RNA(miRNA)표체보,사선출조기위암적특정성miRNA.방법 응용중통량기인심편기술래검측5례조기위암조직급기암방조직표본중miRNA적표체.결과 상대우암방조직,조기위암조직중공유36개miRNA표체하조,여miR-9-1、miR-103、miR-141등；12개miRNA표체상조,여miR-196a、miR-142-3p、miR-25등.결론 재조기위암조직중표체이상적miRNA가능여위암발생발전유착일정적상관성.
Objective To examine the micro-RNA (miRNA) expression profile in tissues of early gastric cancer and to screen the specific miRNA associated with gastric cancer.Methods Gene chip technology was used to detect the expression of miRNA in early gastric cancer tissues and adjacent normal tissues.Results Compared to adjacent normal tissues,a total of 36 miRNAs were downregulated,such as miR-9-1,miR-103 and miR-141,while 12 miRNAs were up-regulated,such as miR-196a,miR-142-3p and miR-25,etc.Conclusion Abnormal miRNA expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
