CAJ | 학술논문

目的探讨影响胃癌根治术后异时性肝转移发生的危险因素.方法回顾性分析天津医科大学肿瘤医院1996-2008年间收治的1 15例胃癌异时性肝转移患者的临床病理资料,分别采用Log-rank检验和Cox模型对影响胃癌异时性肝转移发生的临床病理因素进行单因素和多因素分析.结果胃癌根治术后1、3和5年无肝转移率分别为45.3％、14.8％和3.5％.单因素分析显示,原发瘤部位、大小、分化程度、浸润深度、淋巴结转移、血管浸润、神经浸润、软组织浸润及切除方式与胃癌根治术后肝转移的发生有关(均P＜0.05).多因素分析显示,原发瘤大小、血管浸润、分化程度和淋巴结转移是影响胃癌异时性肝转移发生的独立因素(均P＜0.05).结论原发灶大小、血管浸润、分化程度和淋巴结转移是预估胃癌异时性肝转移发生的重要因素.
목적 탐토영향위암근치술후이시성간전이발생적위험인소.방법 회고성분석천진의과대학종류의원1996-2008년간수치적1 15례위암이시성간전이환자적림상병리자료,분별채용Log-rank검험화Cox모형대영향위암이시성간전이발생적림상병리인소진행단인소화다인소분석.결과 위암근치술후1、3화5년무간전이솔분별위45.3％、14.8％화3.5％.단인소분석현시,원발류부위、대소、분화정도、침윤심도、림파결전이、혈관침윤、신경침윤、연조직침윤급절제방식여위암근치술후간전이적발생유관(균P＜0.05).다인소분석현시,원발류대소、혈관침윤、분화정도화림파결전이시영향위암이시성간전이발생적독립인소(균P＜0.05).결론 원발조대소、혈관침윤、분화정도화림파결전이시예고위암이시성간전이발생적중요인소.
Objective To explore the clinicopathological characteristics and related risk factors in metachronous liver metastasis of gastric cancer.Methods Clinical data of 115 patients with metachronous liver metastasis in Tianjin Medical University Cancer Institute and Hospital between 1996 and 2008 were analyzed retrospectively.Results Among 115 patients,the 1-,3-and 5-year nonhepatic metastasis rates were 45.3％,14.8％ and 3.5％ respectively.Univariate Log-rank test indicated that location,tumor size,tumor differentiation,depth of invasion,lymph node metastasis,vascular invasion,nervous invasion,soft tissue invasion,and modes of gastrectomy were significant factors associated with hepatic metastasis after radical gastrectomy.On multivariate analysis,the size of gastric cancer,vascular invasion,tumor differentiation,and lymph node metastasis were independent factors associated with metachronous liver metastasis of gastric cancer.Conclusions The size of gastric cancer,vascular invasion,tumor differentiation and lymph node metastasis are important factors associated with the risk of hepatic metastasis from gastric cancer in patients after radical gastrectomy.