白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2013年
6期
339-341
,共3页
造血干细胞移植%认知障碍%移植物抗宿主病%小胶质细胞%N-甲基-D-天冬氨酸受体
造血榦細胞移植%認知障礙%移植物抗宿主病%小膠質細胞%N-甲基-D-天鼕氨痠受體
조혈간세포이식%인지장애%이식물항숙주병%소효질세포%N-갑기-D-천동안산수체
Hematopoietic stem cell transplantation%Cognition disorders%Graft vs host disease%Microglia%Receptor,N-methyl-D-aspartic acid
异基因造血干细胞移植(allo-HSCT)后超过50％的患者存在长时程认知功能损害,严重影响生活质量.新近研究提示,allo-HSCT术后的认知功能障碍与移植物抗宿主病(GVHD)相关,其机制是异基因活化的T细胞迁移至中枢神经系统,诱发小胶质细胞等固有组分活化,导致海马区域神经电位发生改变,从而使患者认知功能发生改变.重视患者移植后中枢神经系统病理改变及其对认知功能的影响,早期给予针对性干预措施,有助于患者达到移植后身体、心理和社会功能三方面的完满状态.
異基因造血榦細胞移植(allo-HSCT)後超過50％的患者存在長時程認知功能損害,嚴重影響生活質量.新近研究提示,allo-HSCT術後的認知功能障礙與移植物抗宿主病(GVHD)相關,其機製是異基因活化的T細胞遷移至中樞神經繫統,誘髮小膠質細胞等固有組分活化,導緻海馬區域神經電位髮生改變,從而使患者認知功能髮生改變.重視患者移植後中樞神經繫統病理改變及其對認知功能的影響,早期給予針對性榦預措施,有助于患者達到移植後身體、心理和社會功能三方麵的完滿狀態.
이기인조혈간세포이식(allo-HSCT)후초과50％적환자존재장시정인지공능손해,엄중영향생활질량.신근연구제시,allo-HSCT술후적인지공능장애여이식물항숙주병(GVHD)상관,기궤제시이기인활화적T세포천이지중추신경계통,유발소효질세포등고유조분활화,도치해마구역신경전위발생개변,종이사환자인지공능발생개변.중시환자이식후중추신경계통병리개변급기대인지공능적영향,조기급여침대성간예조시,유조우환자체도이식후신체、심리화사회공능삼방면적완만상태.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a highly successful treatment for hematological malignancies,severe congenital immunodeficiencies and some other diseases.Approximate 50 ％ of the disease-free survival patients suffered from long-lasting severe cognitive impairment after allo-HSCT.Pathological evidences showed parenchymal lymphocytic inflammation,microglia activation,and mild cerebral angiitis-like changes in allogeneic transplanted animals and patients' autopsy.Pay much importance attention to the pathological changes of central nervous system and its impact on cognitive function and take suitable measures would help the patients to achieve a state of complete physical mental and social well-being.
