CAJ | 학술논문

目的：探讨阿立哌唑治疗女性精神分裂症的临床疗效及安全性.方法：将128例女性精神分裂症患者随机分成两组各64例.阿立哌唑组口服阿立哌唑,利培酮组口服利培酮；观察8周.于治疗前及治疗第2周、4周、8周末采用阳性与阴性症状量表评定临床疗效,副反应量表评定不良反应.结果：治疗8周末,阿立哌唑组显效率75.00%,有效率93.75%；利培酮组分别为68.75%、90.63%.两组比较差异均无显著性(χ2=0.59,0.32；P >0.05)；两组不良反应均轻微,但阿立哌唑组锥体外系反应、泌乳和闭经等不良反应发生率低于利培酮组.结论：阿立哌唑治疗女性精神分裂症患者疗效显著,与利培酮疗效相当,且安全性高.
목적：탐토아립고서치료녀성정신분렬증적림상료효급안전성.방법：장128례녀성정신분렬증환자수궤분성량조각64례.아립고서조구복아립고서,리배동조구복리배동；관찰8주.우치료전급치료제2주、4주、8주말채용양성여음성증상량표평정림상료효,부반응량표평정불량반응.결과：치료8주말,아립고서조현효솔75.00%,유효솔93.75%；리배동조분별위68.75%、90.63%.량조비교차이균무현저성(χ2=0.59,0.32；P >0.05)；량조불량반응균경미,단아립고서조추체외계반응、비유화폐경등불량반응발생솔저우리배동조.결론：아립고서치료녀성정신분렬증환자료효현저,여리배동료효상당,차안전성고.
Objective:To explore the clinical efficacy and safety of Aripiprazole and Risperidone in the treatment of female schizophrenia . Methods:134 female patients with schizophrenia were randomly divided into two groups,each group of 67 cases.The Aripiprazole group oral Aripiprazole, Risperidone group oral Risperidone;observation of 8 weeks.In the before treatment and treatment of 2, 4, 8 weekend using the Positive in Negative Syn-drome Scale to evaluate the efficacy,side effects rating scale adverse reactions.Results:In the treatment of 8 weekend,Aripiprazole group markedly effec-tive rate of 75.00%,efficiency of 93.75%;the Risperidone group were 68.75%,90.63%.The difference between the two groups were not significant (χ2=0.59,0.32;P >0.05).Two groups of adverse reactions were mild, but the Aripiprazole group of extrapyramidal system reaction,the body weight in-crease,the incidence of adverse reactions such as lactation and amenorrhea is lower than the Risperidone group .Conclusion:Aripiprazole have significant effect and high safety for treatment of female patients.