CAJ | 학술논문

为评价大麻药不同炮制品对小鼠的急性毒性反应，采用经典的急性毒性实验方法测定了生品、麸制品、姜制品和酒制品的小鼠口服半数致死量（ LD50），观察小鼠急性毒性症状，记录其死亡率和体重变化．结果表明：大麻药生品和3种炮制品的LD50由大到小顺序为姜制品＞麸制品＞生品＞酒制品，LD50值分别为17．93，16．77，12．11，9．45 g· kg-1．怠动、腹泻、心跳加速，唾液分泌增加是主要的急毒症状．故不同的炮制方法对大麻药的毒性影响较大，其毒性成分与中毒机理尚待进一步研究．
위평개대마약불동포제품대소서적급성독성반응，채용경전적급성독성실험방법측정료생품、부제품、강제품화주제품적소서구복반수치사량（ LD50），관찰소서급성독성증상，기록기사망솔화체중변화．결과표명：대마약생품화3충포제품적LD50유대도소순서위강제품＞부제품＞생품＞주제품，LD50치분별위17．93，16．77，12．11，9．45 g· kg-1．태동、복사、심도가속，타액분비증가시주요적급독증상．고불동적포제방법대대마약적독성영향교대，기독성성분여중독궤리상대진일보연구．
To evaluate the acute toxicity effects of the different processed products from Radix Dolichosae on mice, the LD50 value of the raw Radix Dolichosae, the products processed by bran , ginger and wine was determined by the classic methods .The acute toxic symptoms ,the death rate and the weight changes of mice were observed .The results indicated that among the raw Radix Dolichosae and 3 processed products , the LD50 values of the ginger processed product was the highest , then the bran processed product , the raw product ranked third , the wine processed product was the lowest .They are 17.93, 16.77, 12.11 and 9.45 g· kg-1 respectively.Hypokinesia, diarrhea, cardioacceleration and hypersalivation were the main acute toxicity symptoms .So it was concluded that the toxicity of Radix Dolichosae was significantly influenced by the different processing methods .Its toxic components and mechanisms remained further elucidation in the following study .