CAJ | 학술논문

目的：观察络风宁2号对心力衰竭大鼠的心功能的影响。方法60只雄性Wistar大鼠，随机分为正常对照组（n=12），模型组（n=12），络风宁2号组（n=12），风药组（n=12）和芪苈组（n=12）。除正常对照组外，其他各组均按以下方法制备心衰模型，腹腔注射异丙肾上腺素、盐水喂饲，按照所属组别分别进行药物干预。观察大鼠心功能、心脏组织病理学改变。结果与正常对照组比较，其他各实验组心脏质量/体重比均增高（P＜0.01），但实验组间无统计学差异（P＞0.05）。模型组心脏左室舒张末期内径（LVIDd）较正常对照组增大，LVIDd较模型组有所恢复，以络风宁2号组和芪苈组恢复更为明显，但组间比较未见明显差异（P＞0.05），实验组心率、左室收缩末期内径（LVIDs）、左室短轴缩短率（LVFS）、左室射血分数（LVEF）及心肌病理学等变化一致。结论络风宁2号对大鼠心衰有确切治疗作用，疗效与芪苈强心胶囊相当。
목적：관찰락풍저2호대심력쇠갈대서적심공능적영향。방법60지웅성Wistar대서，수궤분위정상대조조（n=12），모형조（n=12），락풍저2호조（n=12），풍약조（n=12）화기력조（n=12）。제정상대조조외，기타각조균안이하방법제비심쇠모형，복강주사이병신상선소、염수위사，안조소속조별분별진행약물간예。관찰대서심공능、심장조직병이학개변。결과여정상대조조비교，기타각실험조심장질량/체중비균증고（P＜0.01），단실험조간무통계학차이（P＞0.05）。모형조심장좌실서장말기내경（LVIDd）교정상대조조증대，LVIDd교모형조유소회복，이락풍저2호조화기력조회복경위명현，단조간비교미견명현차이（P＞0.05），실험조심솔、좌실수축말기내경（LVIDs）、좌실단축축단솔（LVFS）、좌실사혈분수（LVEF）급심기병이학등변화일치。결론락풍저2호대대서심쇠유학절치료작용，료효여기력강심효낭상당。
Objective To observe the influence of Luofengning 2 on heart function in rats with heart failure. Methods Male Wistar rats (n=60) were randomly divided into normal control group, model group, Luofengning 2 group, wind-dispelling medicinal group and Qili Qiangxin Capsules group (each n=12). Except of normal control group, all other groups were injected isoprenaline intraperitoneally for establishing heart failure model and given salt water feeding. All groups were given relevant drugs respectively. The changes of heart function and histopathology were observed. Results Compared with normal control group, the ratio of heart quality to body weight increased in other groups (P<0.01) but there was no statistical difference (P>0.05). The left ventricular end-diastolic inner diameter (LVEDd) increased in model group compared with normal control group, recovered in Luofengning 2 group, wind-dispelling medicinal group and Qili Qiangxin Capsules group compared with model group, which more significant in Luofengning 2 group and Qili Qiangxin Capsules group, but there was no statistical difference (P>0.05). The heart rate, left ventricular end systolic diameter (LVESd), left ventricular fraction shortening (LVFS), left ventricular ejection fraction (LVEF) and myocardial pathological changes were similar in Luofengning 2 group, wind-dispelling medicinal group and Qili Qiangxin Capsules group. Conclusion Luofengning 2 has definite therapeutic effect on heart failure in rats, and its curative effect is similar with that of Qili Qiangxin Capsules.