中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2013年
5期
485-486,539
,共3页
混合静脉血氧饱和度%N末端脑钠肽前体%急性心肌梗死%再灌注治疗
混閤靜脈血氧飽和度%N末耑腦鈉肽前體%急性心肌梗死%再灌註治療
혼합정맥혈양포화도%N말단뇌납태전체%급성심기경사%재관주치료
SVO2%NT-proBNP%Acute myocardial infarction%Reperfusion therapy%Clinical significance
目的：探讨急性心肌梗死（AMI）患者血浆N末端脑钠肽前体（NT-proBNP）和混合静脉血氧饱和度（SvO2）水平与AMI患者预后的关系。方法纳入2011年7月~2012年7月包头市中心医院初发AMI患者且胸痛6h内行再灌注治疗（静脉溶栓或急诊PCI）的患者120例，测定N末端脑钠肽（NT-proBNP）及SvO2，根据以上两结果将入选患者分为A组（n=60，SvO2＞60%、NT-proBNP＜1000 pg/ml）和B组（n=60，SvO2＜60%、NT-proBNP＞1000 pg/ml）。比较两组患者左室射血分数（LVEF）和6个月内心血管不良事件（包括心源性猝死、心源性休克、恶性心律失常）的发生率，并对NT-proBNP和SvO2与不良事件的发生率进行相关性分析。结果治疗后A组患者LVEF高于B组（54.75%±5.18% vs.34.65%±8.11%），同时不良心血管事件发生率明显低于B组（10.0% vs.16.7%），差异均有统计学意义（P＜0.05）。双变量相关分析显示NT-proBNP水平与心血管不良事件发生呈正相关（r=0.474，P＜0.01）；SvO2与不良事件发生呈负相关（r=-0.834，P＜0.01）。结论急性心肌梗死患者NT-BNP＜1000 pg/ml且SvO2＞60%治疗后心功能恢复较好，且预后良好，NT-proBNP和SvO2均与心功能具有相关性。
目的：探討急性心肌梗死（AMI）患者血漿N末耑腦鈉肽前體（NT-proBNP）和混閤靜脈血氧飽和度（SvO2）水平與AMI患者預後的關繫。方法納入2011年7月~2012年7月包頭市中心醫院初髮AMI患者且胸痛6h內行再灌註治療（靜脈溶栓或急診PCI）的患者120例，測定N末耑腦鈉肽（NT-proBNP）及SvO2，根據以上兩結果將入選患者分為A組（n=60，SvO2＞60%、NT-proBNP＜1000 pg/ml）和B組（n=60，SvO2＜60%、NT-proBNP＞1000 pg/ml）。比較兩組患者左室射血分數（LVEF）和6箇月內心血管不良事件（包括心源性猝死、心源性休剋、噁性心律失常）的髮生率，併對NT-proBNP和SvO2與不良事件的髮生率進行相關性分析。結果治療後A組患者LVEF高于B組（54.75%±5.18% vs.34.65%±8.11%），同時不良心血管事件髮生率明顯低于B組（10.0% vs.16.7%），差異均有統計學意義（P＜0.05）。雙變量相關分析顯示NT-proBNP水平與心血管不良事件髮生呈正相關（r=0.474，P＜0.01）；SvO2與不良事件髮生呈負相關（r=-0.834，P＜0.01）。結論急性心肌梗死患者NT-BNP＜1000 pg/ml且SvO2＞60%治療後心功能恢複較好，且預後良好，NT-proBNP和SvO2均與心功能具有相關性。
목적：탐토급성심기경사（AMI）환자혈장N말단뇌납태전체（NT-proBNP）화혼합정맥혈양포화도（SvO2）수평여AMI환자예후적관계。방법납입2011년7월~2012년7월포두시중심의원초발AMI환자차흉통6h내행재관주치료（정맥용전혹급진PCI）적환자120례，측정N말단뇌납태（NT-proBNP）급SvO2，근거이상량결과장입선환자분위A조（n=60，SvO2＞60%、NT-proBNP＜1000 pg/ml）화B조（n=60，SvO2＜60%、NT-proBNP＞1000 pg/ml）。비교량조환자좌실사혈분수（LVEF）화6개월내심혈관불량사건（포괄심원성졸사、심원성휴극、악성심률실상）적발생솔，병대NT-proBNP화SvO2여불량사건적발생솔진행상관성분석。결과치료후A조환자LVEF고우B조（54.75%±5.18% vs.34.65%±8.11%），동시불양심혈관사건발생솔명현저우B조（10.0% vs.16.7%），차이균유통계학의의（P＜0.05）。쌍변량상관분석현시NT-proBNP수평여심혈관불량사건발생정정상관（r=0.474，P＜0.01）；SvO2여불량사건발생정부상관（r=-0.834，P＜0.01）。결론급성심기경사환자NT-BNP＜1000 pg/ml차SvO2＞60%치료후심공능회복교호，차예후량호，NT-proBNP화SvO2균여심공능구유상관성。
Objective To discuss the relationship between the levels of NT-proBNP and SVO2 and prognosis in the patients with acute myocardial infarction (AMI). Methods The patients (n=120) with first-attack AMI were chosen with reperfusion treatment (intravenous thrombolysis or emergency PCI) within 6 h after onset of chest pain from Central Hospital of Baotou City from Jul. 2011 to Jul. 2012. The levels of NT-proBNP and SVO2 were detected and then according to the detecting outcomes, the patients were divided into group A (n=60, SVO2>60%, NT-proBNP<1000 pg/mL) and group B (n=60, SVO2<60%, NT-proBNP>1000 pg/mL). The changes of LVEF, and incidence of major adverse cardiovascular events within 6 months (MACE, including sudden cardiac death, cardiogenic shock, malignant arrhythmia and heart failure) were compared between two groups. The correlation between NT-proBNP and SVO2 and MACE was given Person analysis. Results After treatment, LVEF was higher in group A than that in group B (54.75%±5.18%vs. 34.65%±8.11%), and the incidence of MACE was significantly lower in group A than that in group B (10.0%vs. 16.7%, P<0.05). Person analysis showed that NT-proBNP level was positively correlated to MACE incidence (r=0.474, P<0.01) and SVO2 was negatively correlated to MACE incidence (r=-0.834, P<0.01). Conclusion The heart function recovered well in AMI patients (with NT-BNP<1000 pg/mL and SVO2>60%) after treatment, prognosis is good, and the levels of NT-proBNP and SVO2 are correlated to heart function.
