CAJ | 학술논문

目的：研究卵圆孔未闭（PFO）与中老年隐源性卒中的关系，为中老年隐源性卒中的病因探索提供依据。方法通过检索PubMed、Embase、Web of Science、中国学术期刊网、维普中文科技期刊全文数据库、万方科技期刊全文数据库，选择有关卵圆孔未闭与中老年隐源性卒中的病例对照研究，采用Meta分析方法，通过Stata11.0软件评价两者之间的关系。结果共检索到10篇病例对照研究。Meta分析结果显示，卵圆孔未闭是隐源性卒中的危险因素（OR=2.09，95%CI：1.61～2.71）。单独对经过调整后的OR值合并得到的效应值为2.65（95%CI：1.81～3.88），结果具有统计学意义。亚组分析显示，按照患者年龄下限（55岁）分组后，下限值＜55岁组的效应值降为1.37，达到临界效应（95%CI：1.00～1.88）。按发表时间、对照人群、卒中诊断方法、PFO诊断方法分组后，各亚组的效应值没有发生较大变化，均具有统计学意义（P＜0.05）。结论卵圆孔未闭可能是中老年隐源性卒中的危险因素。
목적：연구란원공미폐（PFO）여중노년은원성졸중적관계，위중노년은원성졸중적병인탐색제공의거。방법통과검색PubMed、Embase、Web of Science、중국학술기간망、유보중문과기기간전문수거고、만방과기기간전문수거고，선택유관란원공미폐여중노년은원성졸중적병례대조연구，채용Meta분석방법，통과Stata11.0연건평개량자지간적관계。결과공검색도10편병례대조연구。Meta분석결과현시，란원공미폐시은원성졸중적위험인소（OR=2.09，95%CI：1.61～2.71）。단독대경과조정후적OR치합병득도적효응치위2.65（95%CI：1.81～3.88），결과구유통계학의의。아조분석현시，안조환자년령하한（55세）분조후，하한치＜55세조적효응치강위1.37，체도림계효응（95%CI：1.00～1.88）。안발표시간、대조인군、졸중진단방법、PFO진단방법분조후，각아조적효응치몰유발생교대변화，균구유통계학의의（P＜0.05）。결론란원공미폐가능시중노년은원성졸중적위험인소。
Objective To study the relationship between patent foramen ovale (PFO) and cryptogenic stroke in middle aged and elderly people, and provide the evidence for etiological research of cryptogenic stroke. Methods The databases of PubMed, Embase, Web of Science, CNKI, VIP and WanFang were retrieved for selecting the case-controlled trials about PFO and cryptogenic stroke in middle aged and elderly people. The relationship between PFO and cryptogenic stroke were analyzed and reviewed by using Meta-analysis and Stata11.0 software. Results There were totally 10 trials obtained. The results of Meta-analysis showed that PFO was the risk factor of cryptogenic stroke (OR=2.09, 95%CI:1.61-2.71). The effect size gotten from pooled OR after adjusting separately was 2.65 (95%CI: 1.81-3.88) which had statistical significance. The results of subgroup analysis showed that the effect size decreased to 1.37 and reached a threshold effect (95%CI:1.00-1.88) in group aged below limiting value<55 after grouping according to the age lower limit (55 years old) of the patients. The effect sizes had no changes in all subgroups (P<0.05) after grouping according to publishing time, control group, stroke diagnostic method and PFO diagnostic method. Conclusion PFO may be a risk factor of cryptogenic stroke in middle aged and elderly people.