CAJ | 학술논문

目的：选择短链氯化石蜡含量不同的两种氯化石蜡产品（CPsⅠ，38.22%和CPsⅡ，0.08%）作为模式化合物，比较它们经口连续灌胃暴露14 d后对SD雄性大鼠的影响，借以探讨短链氯化石蜡是否存在特殊的毒性效应。方法：CPsⅠ和CPsⅡ的暴露浓度分别为10、50、100 mg/kg（CPsⅠ）和100 mg/kg （CPsⅡ）。结果：两种氯化石蜡产品暴露后，对大鼠的摄食、体重无明显影响。CPsⅠ和CPsⅡ急性暴露，均可造成大鼠的肝脏中肝细胞肿胀、水样变性及胞质疏散；肾脏中肾小管肿胀，肾小球萎缩、肾小球玻璃样变；肺部中肺泡隔增厚，炎症细胞浸润等明显的组织病理学改变。结论：氯化石蜡急性暴露对SD雄性大鼠所产生的毒性效应，与样品中短链氯化石蜡的含量并无显著性关联。
목적：선택단련록화석사함량불동적량충록화석사산품（CPsⅠ，38.22%화CPsⅡ，0.08%）작위모식화합물，비교타문경구련속관위폭로14 d후대SD웅성대서적영향，차이탐토단련록화석사시부존재특수적독성효응。방법：CPsⅠ화CPsⅡ적폭로농도분별위10、50、100 mg/kg（CPsⅠ）화100 mg/kg （CPsⅡ）。결과：량충록화석사산품폭로후，대대서적섭식、체중무명현영향。CPsⅠ화CPsⅡ급성폭로，균가조성대서적간장중간세포종창、수양변성급포질소산；신장중신소관종창，신소구위축、신소구파리양변；폐부중폐포격증후，염증세포침윤등명현적조직병이학개변。결론：록화석사급성폭로대SD웅성대서소산생적독성효응，여양품중단련록화석사적함량병무현저성관련。
Objective:Chooses two chlorinated paraffins products which contain different con-tent of short chain chlorinated paraffins(SCCP)as model compound(CPsⅠ,38.22% and CPsⅡ, 0.08%),compares their influence on SD male rats after continuously 14 days being exposed through oral intragastric administration,according to that,to explore whether there is special toxicity of SC-CP or not. Methods:The exposing concentration are 10,50,100(CPsⅠ),100(CPsⅡ)mg/kg,re-spectively. Results:After being exposed under two chlorinated paraffins,there is no obvious influ-ence on food intaking and weight. CPsⅠand CPsⅡ acute exposing,can cause hepatocyte swelling, hydropic degeneration,cytoplast loosen;and renal tubule swelling,glomerulus atrophy,glomerulus hyalinosis;and alveolar septum incrassation,inflammatory cell infiltration;and so on histopatholo-gy changes. Conclusion:Acute chlorinated paraffines exposing has toxicity to SD male rats,the ef-fect has no significant relationship with the content of SCCP.