CAJ | 학술논문

目的：观察阿托伐他汀钙对高脂血症的疗效和安全性。方法将68例高脂血症合并冠心病的老年患者随机均分为观察组和对照组，观察组给予阿托伐他汀钙10 mg ，对照组给予辛伐他汀10 mg ，1d 1次，疗程均为8周，检测并分析患者治疗前后血脂变化、不良反应发生情况和肝功、肌酸激酶水平。结果治疗8周后，观察组总胆固醇（TC）、低密度脂蛋白（LDL-C）和三酰甘油（TG）明显下降，高密度脂蛋白（HDL-C）轻度升高；观察组与对照组差异有统计学意义（P＜0．05）。结论阿托伐他汀能显著降低老年冠心病患者的血脂水平，治疗高脂血症安全有效。
목적：관찰아탁벌타정개대고지혈증적료효화안전성。방법장68례고지혈증합병관심병적노년환자수궤균분위관찰조화대조조，관찰조급여아탁벌타정개10 mg ，대조조급여신벌타정10 mg ，1d 1차，료정균위8주，검측병분석환자치료전후혈지변화、불량반응발생정황화간공、기산격매수평。결과치료8주후，관찰조총담고순（TC）、저밀도지단백（LDL-C）화삼선감유（TG）명현하강，고밀도지단백（HDL-C）경도승고；관찰조여대조조차이유통계학의의（P＜0．05）。결론아탁벌타정능현저강저노년관심병환자적혈지수평，치료고지혈증안전유효。
Objective To explore the effect and safety of atorvastatin calcium in the patients with coronary heart disease complicated with hyperlipidemia .Methods 68 patients with coronary heart disease complicated with hyperlipidemia were randomly divided in-to simvastatin control group and atorvastatin calcium intervention group .The intervention group was taken atorvastatin calcium 10 mg · d-1 for 8 weeks ,and the control group was taken simvastatin 10 mg · d-1 at the same time .After 8 weeks treatment ,the lev-els of lipid ,liver function ,creatine kinase and other adverse reactions of the two groups were observed .Result The levels of serum TC ,LDL-C and TG in intervention group were decreased significantly ,and the level of HDL-C was higher(P<0 .05) .The attacks number of heart failure and angina pectoris increased .Conclusion Atorvastatin calcium can decrease the lipid levels in elderly pa-tients with coronary artery disease ,and it is safe and effective for the hyperlipemia treatment .