CAJ | 학술논문

目的：探讨联合检测甲胎球蛋白（AFP）、糖抗原125（CA125）、糖抗原19-9（CA19-9）在肝细胞癌（HCC）与肝脏转移瘤鉴别诊断中的价值。方法检测93例患者的血清 AFP，CA125和 CA19-9浓度，其中HCC 组45例，肝脏转移瘤组38例，良性肝病组10例。结果①良性肝病组三种标志物均阴性，HCC 组 AFP阳性率明显高于肝脏转移瘤组，且联合检测 AFP、CA125、CA19-9阳性率高达88．9％，明显高于 AFP 单项检测（P ＜0．05）；② HCC 组血清 CA19-9和 CA125阳性率分别为57．8％和77．8％，联合检测 CA19-9、CA125阳性率明显高于肝脏转移瘤组（P ＜0．05）。结论AFP 仍是诊断肝细胞癌的主要血清学肿瘤标志物，联合检测AFP、CA125、CA19-9可明显提高 HCC 的敏感性。
목적：탐토연합검측갑태구단백（AFP）、당항원125（CA125）、당항원19-9（CA19-9）재간세포암（HCC）여간장전이류감별진단중적개치。방법검측93례환자적혈청 AFP，CA125화 CA19-9농도，기중HCC 조45례，간장전이류조38례，량성간병조10례。결과①량성간병조삼충표지물균음성，HCC 조 AFP양성솔명현고우간장전이류조，차연합검측 AFP、CA125、CA19-9양성솔고체88．9％，명현고우 AFP 단항검측（P ＜0．05）；② HCC 조혈청 CA19-9화 CA125양성솔분별위57．8％화77．8％，연합검측 CA19-9、CA125양성솔명현고우간장전이류조（P ＜0．05）。결론AFP 잉시진단간세포암적주요혈청학종류표지물，연합검측AFP、CA125、CA19-9가명현제고 HCC 적민감성。
Objective To explore the differential diagnosis value of combination detection of serum alpha-fe-toprotein (AFP),Carbohydrate antigens 125 (CA125)and Carbohydrate antigens 19-9(CA19-9)between hepatocel-lular carcinoma (HCC)and liver metastases.Methods The level of serum AFP,CA125 and CA19-9 were detected in 95 patients,including 45 cases of HCC,38 cases of liver metastases,and 10 cases of benign liver disease.Results ① Three markers in patients with benign liver disease were all negative.The positive rate of serum AFP was in-creased significantly (P <0.05)in patients with HCC compared with liver metastases,and the positive rate of joint detection of AFP,CA125 and CA19-9 was 88.9%,which were significantly (P <0.05)higher than AFP detection,② The positive rate of serum CA19-9 and CA125 were 57.8% and 77.8%,respectively,and the positive rate of de-tection of CA19-9 and CA125 significantly (P <0.05)higher in patients with HCC than those of patients with liver metastases.Conclusion AFP is still one of the most important tumor markers in the diagnosis of HCC.Combined de-tection of serum AFP,CA125 and CA19-9 can significantly improve the sensitivity of HCC.