CAJ | 학술논문

目的：分析多重耐药鲍曼不动杆菌与多重耐药铜绿假单胞菌的耐药性，为临床治疗提供依据。方法用 VITEK-32微生物自动鉴定与药敏系统，对临床分离出的非重复铜绿假单胞菌56株、鲍曼不动杆菌72株进行鉴定、药敏试验，并对比分析两种菌的耐药性。结果鲍曼不动杆菌对阿米卡星、左氧氟沙星的耐药率最低，分别为2．8％和68．1％。铜绿假单胞菌对哌拉西林/他唑巴坦的耐药率最低，为19．6％，其次为阿米卡星与亚胺培南，均为37．5％。鲍曼不动杆菌对哌拉西林/他唑巴坦、庆大霉素、妥布霉素、氨曲南、环丙沙星、左氧氟沙星、头孢吡肟、头孢他啶和亚胺培南的耐药率明显高于铜绿假单胞菌，差异有统计学意义（P ＜0．01或 P ＜0．05），只有对阿米卡星的耐药率低于铜绿假单胞菌（P ＜0．01）。71．7％的鲍曼不动杆菌只对阿米卡星敏感，鲍曼不动杆菌的多重耐药率（97．2％）显著高于铜绿假单胞菌（67．9％），P ＜0．01。结论铜绿假单胞菌、鲍曼不动杆菌的多重耐药现象严重，尤其是鲍曼不动杆菌，应加强耐药性监测。
목적：분석다중내약포만불동간균여다중내약동록가단포균적내약성，위림상치료제공의거。방법용 VITEK-32미생물자동감정여약민계통，대림상분리출적비중복동록가단포균56주、포만불동간균72주진행감정、약민시험，병대비분석량충균적내약성。결과포만불동간균대아미잡성、좌양불사성적내약솔최저，분별위2．8％화68．1％。동록가단포균대고랍서림/타서파탄적내약솔최저，위19．6％，기차위아미잡성여아알배남，균위37．5％。포만불동간균대고랍서림/타서파탄、경대매소、타포매소、안곡남、배병사성、좌양불사성、두포필우、두포타정화아알배남적내약솔명현고우동록가단포균，차이유통계학의의（P ＜0．01혹 P ＜0．05），지유대아미잡성적내약솔저우동록가단포균（P ＜0．01）。71．7％적포만불동간균지대아미잡성민감，포만불동간균적다중내약솔（97．2％）현저고우동록가단포균（67．9％），P ＜0．01。결론동록가단포균、포만불동간균적다중내약현상엄중，우기시포만불동간균，응가강내약성감측。
Objective To analysis multidrug-resistant of Pseudomonas aeruginosa and Acinetobacter bau-mannii isolated from hospitalized patients and provide reliable reference for rational clinical use of antibiotics.Meth-ods The identification and antibiotics resistance test of 56 strains of Pseudomonas aeruginosa and 72 stranis of Acin-etobacter baumannii isolated from patients in emergency department from May 2009 to Oct 2011 were performed by VITEK-32 system.Results The resistance rate of Acinetobacter baumannii to Amikacin was the lowest (2.8%),fol-lowed by Levofloxacin(68.1%).The antibiotics resistance rate of Pseudomonas aeruginosa to Piperacillin/tazobactam was lowest(19.6%),followed by Amikacin and Imipenem(37.5%).The antibiotics resistance rate of Acinetobacter baumannii to Piperacillin/tazobactam,Gentamycin,Tobramycins,Aztreonam,Levofloxacin,Ciprofloxacin,Ceftazidime, Cefepime and Imipenem were significantly higher than that of Pseudomonas aeruginosa (P <0.01 or P <0.05),ex-cept for Amikacin,the resistance rate of Acinetobacter baumannii was lower than that of Pseudomonas aeruginosa (P<0.01).The multidrug-resistant rate of Acinetobacter baumannii (97.2%)was significantly higher than that of Pseudomonas aeruginosa(67.9%)(P <0.01),with 71.7% of Acinetobacter baumannii was only sensitive to Ami-kacin.Conclusion The multidrug-resistant rates of Pseudomonas aeruginosa and Acinetobacter baumannii are high, especialy for Acinetobacter baumannii.The antibiotics resistance monitoring and rational use should be paid more at-tention according to the results of drug susceptibility test.