西北药学杂志
西北藥學雜誌
서북약학잡지
2013年
6期
617-618
,共2页
淫羊藿苷%羟丙基-β-环糊精%相溶解度法
淫羊藿苷%羥丙基-β-環糊精%相溶解度法
음양곽감%간병기-β-배호정%상용해도법
icariin%hydroxylpropyl-β-cyclodextrin%phase solubility method
目的:利用相溶解度曲线法研究不同质量浓度的羟丙基-β-环糊精对淫羊藿苷溶解度的影响。方法配制一系列质量浓度的HP-β-CD溶液,加入过量的淫羊藿苷,绘制不同温度下的相溶解度图。结果相溶解度曲线为线性关系,包合模型为AL型,淫羊藿苷与HP-β-CD以1∶1的比例包合。在25,35和45℃时,其表观结合常数分别为52.01,64.66和41.42 L · mmol-1。结论 H P-β-CD对淫羊藿苷有一定的增溶作用。
目的:利用相溶解度麯線法研究不同質量濃度的羥丙基-β-環糊精對淫羊藿苷溶解度的影響。方法配製一繫列質量濃度的HP-β-CD溶液,加入過量的淫羊藿苷,繪製不同溫度下的相溶解度圖。結果相溶解度麯線為線性關繫,包閤模型為AL型,淫羊藿苷與HP-β-CD以1∶1的比例包閤。在25,35和45℃時,其錶觀結閤常數分彆為52.01,64.66和41.42 L · mmol-1。結論 H P-β-CD對淫羊藿苷有一定的增溶作用。
목적:이용상용해도곡선법연구불동질량농도적간병기-β-배호정대음양곽감용해도적영향。방법배제일계렬질량농도적HP-β-CD용액,가입과량적음양곽감,회제불동온도하적상용해도도。결과상용해도곡선위선성관계,포합모형위AL형,음양곽감여HP-β-CD이1∶1적비례포합。재25,35화45℃시,기표관결합상수분별위52.01,64.66화41.42 L · mmol-1。결론 H P-β-CD대음양곽감유일정적증용작용。
Objective To study the effect of different concentrations of hydroxylpropyl-β-cyclodextrin on the solubility of icariin u-sing phase solubility method .Methods Different concentrations of hydroxylpropyl-β-cyclodextrin were prepared ,overdose icariin was added ,and the phase solubility diagram was made at different temperatures .Result The relationship of phase solubility was approximatively linear and AL model of inclusion compound and the inclusion ration of icariin versus hydroxylpropyl-β-cyclodextrin was 1∶1 .The apparent stability constants at 25 ,35 and 45 ℃ was 52 .01 ,64 .66 and 41 .42 L · mmol-1 respectively .Conclusion HP-β-CD could evidently increase the solubility of icariin .