CAJ | 학술논문

目的：对大籽獐牙菜乙醇提取物在解酒保肝方面的作用进行初步研究探讨。方法采用纠正运动失调作用实验、解酒实验和预防醉酒实验，同时测定急性酒精性肝损伤小鼠的血清丙氨酸转换酶（ALT）和肝糖原的含量。结果大籽獐牙菜醇提取物可显著延长小鼠酒后在网停留时间；使给药组的翻正反射恢复时间较对照组显著缩短；给药后醉酒小鼠数较未给药组显著减少；可对抗乙醇对小鼠肝脏造成的损伤，使谷丙转氨酶活力显著下降，促进肝糖原的分解，对抗乙醇造成的低血糖。结论大籽獐牙菜提取物具有纠正运动失调、解酒以及预防酒醉作用，其对乙醇所致的肝损伤有防治作用。
목적：대대자장아채을순제취물재해주보간방면적작용진행초보연구탐토。방법채용규정운동실조작용실험、해주실험화예방취주실험，동시측정급성주정성간손상소서적혈청병안산전환매（ALT）화간당원적함량。결과대자장아채순제취물가현저연장소서주후재망정류시간；사급약조적번정반사회복시간교대조조현저축단；급약후취주소서수교미급약조현저감소；가대항을순대소서간장조성적손상，사곡병전안매활력현저하강，촉진간당원적분해，대항을순조성적저혈당。결론대자장아채제취물구유규정운동실조、해주이급예방주취작용，기대을순소치적간손상유방치작용。
Objective To observe the preventive effect of Swertia macrosperma extracts on acute alcohol-induced liver injury . Methods The test of ataxia function was performed to evaluate the anti-alcoholism and drunkenness prevention effect .Mean-while ,the ALT and hepatic glycogen were determined .Results The Swertia macrosperma ethanol extracts can significantly ex-tend the time of the mice drunken ;The time of regaining the right reflex for the medicated group was shorter than that of the con-trol group;the number of drunk mice after treatment was significantly reduced than that of the non-administered group .Conclu-sion Swertia macrosperma extracts have protective effects on acute alcohol-induced liver injury .