CAJ | 학술논문

目的：观察沙棘黄酮与阿伐他汀联用对实验性高脂血症模型金黄地鼠的影响。方法给予金黄地鼠高脂饲料4周，造成高血脂金黄地鼠模型，同时灌胃给沙棘黄酮与阿伐他汀组合药物。4周后测定高脂模型金黄地鼠三酰甘油（T G ）、总胆固醇（CHO）、低密度脂蛋白胆固醇（LDLC）、高密度脂蛋白胆固醇（HDLC）、组织病理学。结果阿伐他汀＋沙棘黄酮组与模型组比较对于血脂各成分CHOL、HDL、LDL、TG具有显著的影响（P＜0．05或0．001），并能改善高脂血症引起的金黄地鼠病理学异常。结论沙棘黄酮与阿伐他汀联用具有更好的协同作用，并能明显改善高脂血症。
목적：관찰사극황동여아벌타정련용대실험성고지혈증모형금황지서적영향。방법급여금황지서고지사료4주，조성고혈지금황지서모형，동시관위급사극황동여아벌타정조합약물。4주후측정고지모형금황지서삼선감유（T G ）、총담고순（CHO）、저밀도지단백담고순（LDLC）、고밀도지단백담고순（HDLC）、조직병이학。결과아벌타정＋사극황동조여모형조비교대우혈지각성분CHOL、HDL、LDL、TG구유현저적영향（P＜0．05혹0．001），병능개선고지혈증인기적금황지서병이학이상。결론사극황동여아벌타정련용구유경호적협동작용，병능명현개선고지혈증。
Objective To observe the influence of the combination of seabuckthorn flavone and atorvastatin on blood lipid in experi-mental hyperlipidemia golden hamster .Methods Golden hamster were given high fat diet for 4 weeks ,resulting in the model of hy-perlipidemia ,meanwhile the modified three kind of combinations of seabuckthorn flavone and atorvastatin were given for 4 weeks . During the drug administration ,the levels of TG ,CHO ,LDLC ,HDLC ,and the histopathologic changes were measured and ob-served .Results Compared with the model group ,combinations of seabuckthorn flavone and atorvastatin group could reduce the contents of TG ,CHO ,LDLC ,and HDLC in golden hamster serum obviously (P<0 .01) ,could improve the hemorrheologic and hyperlipidemia abnormality .Conclusion The combinations of seabuckthorn flavone and atorvastatin shows clear improvement for hyperlipidemia-related indicators .