临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2013年
6期
498-500
,共3页
戎伟%何思忠%万承龙%朱翠珍%夏晓慧%李江波
戎偉%何思忠%萬承龍%硃翠珍%夏曉慧%李江波
융위%하사충%만승룡%주취진%하효혜%리강파
抑郁症%精神病性症状%文拉法辛%帕罗西汀%汉密顿抑郁量表%副反应量表
抑鬱癥%精神病性癥狀%文拉法辛%帕囉西汀%漢密頓抑鬱量錶%副反應量錶
억욱증%정신병성증상%문랍법신%파라서정%한밀돈억욱량표%부반응량표
Depression%psychotic symptom%venlafaxine%paroxetine%HAMD%TESS
目的:探讨文拉法辛缓释片与帕罗西汀治疗无精神病性症状抑郁症的临床疗效和安全性。方法将84例无精神病性症状的抑郁症患者随机分为两组,每组42例,观察组口服文拉法辛缓释片治疗,对照组口服帕罗西汀治疗,观察8周。治疗前后采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果治疗2周末观察组汉密顿抑郁量表评分较对照组下降更显著( P<0.01);治疗8周末,观察组总有效率为78.57%,对照组为76.19%,两组总有效率比较差异无显著性(P>0.05)。两组不良反应均较轻微,发生率比较差异无显著性(P>0.05)。结论文拉法辛缓释片与帕罗西汀治疗抑郁症效果均显著,安全性高、依从性好,但文拉法辛缓释剂起效更快,值得临床推广应用。
目的:探討文拉法辛緩釋片與帕囉西汀治療無精神病性癥狀抑鬱癥的臨床療效和安全性。方法將84例無精神病性癥狀的抑鬱癥患者隨機分為兩組,每組42例,觀察組口服文拉法辛緩釋片治療,對照組口服帕囉西汀治療,觀察8週。治療前後採用漢密頓抑鬱量錶評定臨床療效,副反應量錶評定不良反應。結果治療2週末觀察組漢密頓抑鬱量錶評分較對照組下降更顯著( P<0.01);治療8週末,觀察組總有效率為78.57%,對照組為76.19%,兩組總有效率比較差異無顯著性(P>0.05)。兩組不良反應均較輕微,髮生率比較差異無顯著性(P>0.05)。結論文拉法辛緩釋片與帕囉西汀治療抑鬱癥效果均顯著,安全性高、依從性好,但文拉法辛緩釋劑起效更快,值得臨床推廣應用。
목적:탐토문랍법신완석편여파라서정치료무정신병성증상억욱증적림상료효화안전성。방법장84례무정신병성증상적억욱증환자수궤분위량조,매조42례,관찰조구복문랍법신완석편치료,대조조구복파라서정치료,관찰8주。치료전후채용한밀돈억욱량표평정림상료효,부반응량표평정불량반응。결과치료2주말관찰조한밀돈억욱량표평분교대조조하강경현저( P<0.01);치료8주말,관찰조총유효솔위78.57%,대조조위76.19%,량조총유효솔비교차이무현저성(P>0.05)。량조불량반응균교경미,발생솔비교차이무현저성(P>0.05)。결논문랍법신완석편여파라서정치료억욱증효과균현저,안전성고、의종성호,단문랍법신완석제기효경쾌,치득림상추엄응용。
Objective To explore the efficacy and safety of venlafaxine sustained-release tablets vs .parox-etine in depression without psychotic symptoms .Methods Eighty-four depression patients without psy-chotic symptoms were randomly assigned to two groups of 42 ones each ,observation group took orally venlafaxine sustained-release tablets and control group did paroxetine for 8 weeks .Clinical efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 2nd week the HAMD score lowered more significantly in observation than control group (P<0 .01);at the end of the 8th week total effective rate were respectively 78 .57% in observation and 76 .19% in control group ,which showed no significant difference (P>0 .05) .Adverse reactions of both groups were mild ,their incidences had no significant group differences (P>0 .05) .Conclusion Both venlafaxine sustained-release tablets and parox-etine have an evident effect in depression ,higher safety and better compliance ,but the former takes effect more rapidly and deserves to be clinically spread and utilized .