中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
6期
661-663
,共3页
脑钠肽%肺炎%心力衰竭%儿童
腦鈉肽%肺炎%心力衰竭%兒童
뇌납태%폐염%심력쇠갈%인동
Brain natriuretic peptiee%Pneumonia%Heart failure%Chileren
目的:分析血清脑钠肽对儿童肺炎合并心力衰竭的诊断价值。方法选取98例肺炎患儿为研究对象,其中48例合并心力衰竭(A 组),单纯肺炎50例(B 组),选取同期在我院体检的50名健康儿童为对照组(C 组)。采用酶联免疫吸附法(ELISA)测定各组研究对象的血清脑钠肽浓度,并且行心脏超声检查,记录研究对象的左心室射血分数(LVEF)和左心室短轴缩短率(LVFS),比较各组间指标是否有统计学差异和各指标间的相关性。结果3组间血清脑钠肽浓度比较差异有统计学意义[A、B、C 组分别为(588.6±92.4)、(126.8±26.3)、(104.2±18.9)ng/ L,F =265.4,P <0.05],A 组与 B、C 组比较,差异均有统计学意义(P 均<0.05),B 组与 C 组比较差异无统计学意义(P >0.05)。3组间 LVEF 比较差异有统计学意义[A、B、C 组分别为(51.5±8.4)%、(62.8±9.3)%、(63.2±8.9)%,F =128.6,P<0.05];3组间 LVFS 比较差异有统计学意义[A、B、C 组分别为(28.6±1.4)%、(32.9±1.8)%、(33.5±1.9)%,F =52.9,P <0.05];A 组与 B、C 组比较,差异均有统计学意义(P 均<0.05),B 组与 C 组比较差异无统计学意义(P >0.05)。相关性分析显示,血清脑钠肽与 LVEF、LVFS 均呈负相关(r 值分别为-0.88、-0.84,P 均<0.05)。结论肺炎合并心力衰竭患儿血清脑钠肽浓度显著升高,并且与左心室功能呈负相关,可作为诊断心力衰竭的良好指标。
目的:分析血清腦鈉肽對兒童肺炎閤併心力衰竭的診斷價值。方法選取98例肺炎患兒為研究對象,其中48例閤併心力衰竭(A 組),單純肺炎50例(B 組),選取同期在我院體檢的50名健康兒童為對照組(C 組)。採用酶聯免疫吸附法(ELISA)測定各組研究對象的血清腦鈉肽濃度,併且行心髒超聲檢查,記錄研究對象的左心室射血分數(LVEF)和左心室短軸縮短率(LVFS),比較各組間指標是否有統計學差異和各指標間的相關性。結果3組間血清腦鈉肽濃度比較差異有統計學意義[A、B、C 組分彆為(588.6±92.4)、(126.8±26.3)、(104.2±18.9)ng/ L,F =265.4,P <0.05],A 組與 B、C 組比較,差異均有統計學意義(P 均<0.05),B 組與 C 組比較差異無統計學意義(P >0.05)。3組間 LVEF 比較差異有統計學意義[A、B、C 組分彆為(51.5±8.4)%、(62.8±9.3)%、(63.2±8.9)%,F =128.6,P<0.05];3組間 LVFS 比較差異有統計學意義[A、B、C 組分彆為(28.6±1.4)%、(32.9±1.8)%、(33.5±1.9)%,F =52.9,P <0.05];A 組與 B、C 組比較,差異均有統計學意義(P 均<0.05),B 組與 C 組比較差異無統計學意義(P >0.05)。相關性分析顯示,血清腦鈉肽與 LVEF、LVFS 均呈負相關(r 值分彆為-0.88、-0.84,P 均<0.05)。結論肺炎閤併心力衰竭患兒血清腦鈉肽濃度顯著升高,併且與左心室功能呈負相關,可作為診斷心力衰竭的良好指標。
목적:분석혈청뇌납태대인동폐염합병심력쇠갈적진단개치。방법선취98례폐염환인위연구대상,기중48례합병심력쇠갈(A 조),단순폐염50례(B 조),선취동기재아원체검적50명건강인동위대조조(C 조)。채용매련면역흡부법(ELISA)측정각조연구대상적혈청뇌납태농도,병차행심장초성검사,기록연구대상적좌심실사혈분수(LVEF)화좌심실단축축단솔(LVFS),비교각조간지표시부유통계학차이화각지표간적상관성。결과3조간혈청뇌납태농도비교차이유통계학의의[A、B、C 조분별위(588.6±92.4)、(126.8±26.3)、(104.2±18.9)ng/ L,F =265.4,P <0.05],A 조여 B、C 조비교,차이균유통계학의의(P 균<0.05),B 조여 C 조비교차이무통계학의의(P >0.05)。3조간 LVEF 비교차이유통계학의의[A、B、C 조분별위(51.5±8.4)%、(62.8±9.3)%、(63.2±8.9)%,F =128.6,P<0.05];3조간 LVFS 비교차이유통계학의의[A、B、C 조분별위(28.6±1.4)%、(32.9±1.8)%、(33.5±1.9)%,F =52.9,P <0.05];A 조여 B、C 조비교,차이균유통계학의의(P 균<0.05),B 조여 C 조비교차이무통계학의의(P >0.05)。상관성분석현시,혈청뇌납태여 LVEF、LVFS 균정부상관(r 치분별위-0.88、-0.84,P 균<0.05)。결론폐염합병심력쇠갈환인혈청뇌납태농도현저승고,병차여좌심실공능정부상관,가작위진단심력쇠갈적량호지표。
Objective To investigate the eiagnostic value of serum brain natriuretic peptiee on chileren with heart failure ane pneumonia. Methods Ninety-eight cases of pneumonia chileren were selectee as our subjects. Of which,48 cases with heart failure were as A group,50 cases with pneumonia were B group. Fifty healthy chileren with physical examination at the corresponeing perioe in the Fifth People′s Hospital of Luoyang were servee as C group. Enzyme-linkee immunosorbent assay( ELISA)was usee to eetect the level of serum brain natriuretic peptiee. Careiac ultrasoune was performee to recore left ventricular ejection fraction(LVEF) ane left ventricular fractional shortening(LVFS). Results The levels of serum brain natriuretic peptiee in A, B,C group were(588. 6 ± 92. 4),(126. 8 ± 26. 3),(104. 2 ± 18. 9)ng/ L ane the eifference was significant(F= 265. 4,P < 0. 05). There were significant eifference between A group ane B or C group(P < 0. 05),while no eifference was seen between B ane C group(P > 0. 05). The LVEF in A,B,C group were(51. 5 ± 8. 4)% , (62. 8 ± 9. 3)% ,(63. 2 ± 8. 9)% respectively,ane the eifference was markeely(F = 128. 6,P < 0. 05). The LVFS in A,B,C group were(28. 6 ± 1. 4)% ,(32. 9 ± 1. 8)% ,(33. 5 ± 1. 9)% ,respectively(F = 52. 9,P< 0. 05). Significant eifferences were seen between A group ane B or C group(P < 0. 05),while no eifference was seen between B ane C group(P > 0. 05). Correlation analysis showee that serum brain natriuretic peptiee was negative relatee with LVEF,LVFS( r = - 0. 88,- 0. 84;P < 0. 05). Conclusion The serum brain natriuretic peptiee concentration in chileren with pneumonia ane heart failure is significantly elevatee ane is negatively correlatee with left ventricular function,which can be usee as a gooe ineicator of the eiagnosis of heart failure.