CAJ | 학술논문

目的：研究急性缺氧和短期缺氧适应对三尖瓣返流的影响。方法从2012年5～9月共入选176例健康青年男性。利用彩色超声多普勒技术采集急性缺氧（氧浓度12％）前后三尖瓣返流的相关参数（返流面积、返流压差、最大返流速度），分析急性缺氧前后三尖瓣返流发生和缓解的情况。结果与常氧组相比，急性缺氧组三尖瓣返流率（76％vs 48％）、返流压差（25．65 mmHg vs 19．33 mmHg）、最大返流速度（251．38 cm/s vs 220．62 cm/s）明显升高，而返流面积无明显差异。与急性缺氧组相比，缺氧2周组三尖瓣返流率（50％vs 76％）、返流压差（20．83 mmHg vs 25．65 mmHg）、最大返流速度（225．69 cm/s vs 251．38cm/s）明显下降，而返流面积则无明显差异。结论急性缺氧促进并加重三尖瓣返流，而短期的缺氧适应可以逆转该过程。
목적：연구급성결양화단기결양괄응대삼첨판반류적영향。방법종2012년5～9월공입선176례건강청년남성。이용채색초성다보륵기술채집급성결양（양농도12％）전후삼첨판반류적상관삼수（반류면적、반류압차、최대반류속도），분석급성결양전후삼첨판반류발생화완해적정황。결과여상양조상비，급성결양조삼첨판반류솔（76％vs 48％）、반류압차（25．65 mmHg vs 19．33 mmHg）、최대반류속도（251．38 cm/s vs 220．62 cm/s）명현승고，이반류면적무명현차이。여급성결양조상비，결양2주조삼첨판반류솔（50％vs 76％）、반류압차（20．83 mmHg vs 25．65 mmHg）、최대반류속도（225．69 cm/s vs 251．38cm/s）명현하강，이반류면적칙무명현차이。결론급성결양촉진병가중삼첨판반류，이단기적결양괄응가이역전해과정。
Objective To explore the effect of acute hypoxia on tricuspid regurgitation .Methods 176 healthy young males were selected and their tricuspid regurgitation parameters in normoxia and after acute exposure to hypoxia ( oxygen concentrations 12%) were collected by color Doppler technology .The conditions of tricuspid regurgitation were compared between the two groups .Results Tricuspid regurgitation was significantly increased after the subjects were exposed to hypoxia.Tricuspid regurgitation rate (76% vs 48%), regurgitation pressure (25.65 mmHg vs 19.33 mmHg) and maxi-mum regurgitation velocity (251.38 cm/s vs 220.62 cm/s) were higher in the hypoxia group .However, there was no significant change in the regurgitation area .After two weeks of adaptation to hypoxia , the tricuspid regurgitation rate (50%vs 76%), regurgitation pressure (20.83 mmHg vs 25.65 mmHg) and maximum regurgitation velocity (225.69 cm/s vs 251.38 cm/s) significantly decreased and returned to the level before hypoxic exposure .Conclusion Acute hypoxic expo-sure can induce and aggravate tricuspid regurgitation ,and short-term adaptation to hypoxia can reverse the trend .