CAJ | 학술논문

目的：探讨阿托伐他汀钙联合缬沙坦治疗高血压伴左心室肥厚的疗效。方法选取血脂正常的原发性高血压患者100例,按随机数字表法随机分成对照组50例，治疗组50例。对照组口服缬沙坦80mg，1次/d，2w后，如果收缩压≥140mmHg或舒张压≥90mmHg，则增加至160mg，1次/d。治疗组联用阿托伐他汀钙20mg,每晚1次。两组均随访治疗1年。结果两组治疗前、后血压比较，差异有统计学意义（P<0.05），但两组间治疗后血压比较,差异无统计学意义（P>0.05）。两组治疗前、后左心室重量指数比较，差异有统计学意义（P<0.05）。结论阿托伐他汀钙联合缬沙坦治疗高血压伴左心室肥厚疗效确切，值得临床推广。
목적：탐토아탁벌타정개연합힐사탄치료고혈압반좌심실비후적료효。방법선취혈지정상적원발성고혈압환자100례,안수궤수자표법수궤분성대조조50례，치료조50례。대조조구복힐사탄80mg，1차/d，2w후，여과수축압≥140mmHg혹서장압≥90mmHg，칙증가지160mg，1차/d。치료조련용아탁벌타정개20mg,매만1차。량조균수방치료1년。결과량조치료전、후혈압비교，차이유통계학의의（P<0.05），단량조간치료후혈압비교,차이무통계학의의（P>0.05）。량조치료전、후좌심실중량지수비교，차이유통계학의의（P<0.05）。결론아탁벌타정개연합힐사탄치료고혈압반좌심실비후료효학절，치득림상추엄。
Objective To study the atorvastatin calcium in combination with valsartan treatment the curative ef ect of hypertension with left ventricular hypertrophy. Methods Blood lipids of 100 cases of patients with essential hypertension,selected by random number table method 50 cases randomly divided into control group, treatment group 50 cases.The control group oral valsartan 80 mg, 1/d, after 2 weeks,if 140 mmHg or diastolic systolic blood pressure or greater acuity 90 mmHg,rose to 160 mg,1/d.Treatment group with atorvastatin 20 mg calcium,once every night.In the two groups were fol owed for 1 year treatment.Results Compared the two groups before and after treatment of blood pressure,the dif erence was statistical y significant (P<0.05),but blood pressure after treatment between two groups,there was no statistical y significant dif erence (P>0.05).The two groups before treatment and after left ventricular mass index comparison,the dif erence was statistical y significant (P<0.05).Conclusion Atorvastatin calcium in combination with valsartan treatment of hypertension with left ventricular hypertrophy curative ef ect,worth clinical promotion.