CAJ | 학술논문

目的：探讨冻干重组人脑利钠太治疗顽固性心力衰竭的临床效果。方法选取新疆自治区人民医院心内科 CCU室2011年1月~2012年12月收治的56例顽固性心力衰竭患者，随机分为对照组及治疗组，每组28例，对照组采用常规传统心力衰竭治疗，治疗组在对照组的基础上应用重组人脑钠肽，比较两组患者的临床治疗效果。结果在总有效率及BNP及LVEF的改善上治疗组改善均优于对照组，组间差异有统计学意义(P＜0.05)，两组在治疗期间均无明显不良反应。结论重组人脑钠肽对于顽固性心力衰竭疗效由于传统疗法，不良反应少，适合临床使用。
목적：탐토동간중조인뇌리납태치료완고성심력쇠갈적림상효과。방법선취신강자치구인민의원심내과 CCU실2011년1월~2012년12월수치적56례완고성심력쇠갈환자，수궤분위대조조급치료조，매조28례，대조조채용상규전통심력쇠갈치료，치료조재대조조적기출상응용중조인뇌납태，비교량조환자적림상치료효과。결과재총유효솔급BNP급LVEF적개선상치료조개선균우우대조조，조간차이유통계학의의(P＜0.05)，량조재치료기간균무명현불량반응。결론중조인뇌납태대우완고성심력쇠갈료효유우전통요법，불량반응소，괄합림상사용。
Objective To study lyophilized recombinant human brain natriuretic clinical ef ect to refractory heart failure.Methods Xinjiang Autonomous Region People's Hospital CCU room in January 2011-2012 December 56 treated patients with refractory heart failure were randomly divided into a control group and the treatment group, 28 cases in the control group using conventional traditional ef ort failure treatment group recombinant human brain natriuretic peptide in the control group on the basis of the clinical treatment of patients were compared. Results The total ef iciency improvement of LVEF and BNP and improve treatment groups than the control group between the two groups was statistical y significant (P<0.05) dif erences between the two groups during the treatment had no significant adverse reactions.Conclusion The recombinant human brain natriuretic peptide for refractory heart failure due to the traditional therapy ef icacy,fewer side ef ects,suitable for clinical use.