CAJ | 학술논문

目的：检测脓毒症患儿血液可溶性血红蛋白清道夫受体（ sCD163）表达的变化，探讨其相关的临床意义。方法：收集脓毒症患儿62例，另取本院同期健康体检的儿童30例作为正常对照。sCD163表达的测定使用 ELISA 法。结果：脓毒症患儿中sCD163的表达水平为63．7±5．6 U/ml显著高于健康对照组儿童的15．2±2．1U/ml。好转组第1、3、7天sCD163的表达分别为58．2±4．7、31．6±3．5和22．3±2．4U/ml ，恶化组第1、3、7天sCD163的表达分别为92．4±7．5、103．8±8．2和113．9±8．6U/ml ，第1、3、7天时恶化组sCD163的表达水平均显著高于好转组，随着时间的推移好转组sCD163的表达水平逐渐减低，而恶化组sCD163的表达水平则逐渐升高。结论：sCD163表达的升高可能参与了脓毒症病变的发生、发展过程，sCD163的检测有可能成为脓毒症患儿的早期诊断以及预后评估指标。
목적：검측농독증환인혈액가용성혈홍단백청도부수체（ sCD163）표체적변화，탐토기상관적림상의의。방법：수집농독증환인62례，령취본원동기건강체검적인동30례작위정상대조。sCD163표체적측정사용 ELISA 법。결과：농독증환인중sCD163적표체수평위63．7±5．6 U/ml현저고우건강대조조인동적15．2±2．1U/ml。호전조제1、3、7천sCD163적표체분별위58．2±4．7、31．6±3．5화22．3±2．4U/ml ，악화조제1、3、7천sCD163적표체분별위92．4±7．5、103．8±8．2화113．9±8．6U/ml ，제1、3、7천시악화조sCD163적표체수평균현저고우호전조，수착시간적추이호전조sCD163적표체수평축점감저，이악화조sCD163적표체수평칙축점승고。결론：sCD163표체적승고가능삼여료농독증병변적발생、발전과정，sCD163적검측유가능성위농독증환인적조기진단이급예후평고지표。
Objective :To investigate the expression and clinical significance of sCD 163 in children with sepsis .Methods :62 children with sepsis were enrolled in our study .Another 30 healthy children were used as a nor-mal control ..The expression of sCD163 was detected by ELISA analysis .Results :The expression of sCD163 in sep-sis group was 63 .7 ± 5 .6 U/ml ,and which was higher than that of 15 .2 ± 2 .1U/ml in control group .The expres-sion of sCD163 in improve group was 58 .2 ± 4 .7 ,31 .6 ± 3 .5 ,and 22 .3 ± 2 .4U/ml at 1 ,3 ,7 day .The expression of sCD163 in deterioration group was 92 .4 ± 7 .5 ,103 .8 ± 8 .2 ,and 113 .9 ± 8 .6U/ml at 1 ,3 ,7 day .The sCD163 expression was higher in deterioration group than that in improve group at 1 ,3 ,7 day .The expression of sCD163 in improve group was decreased ,according to time reducing .The expression of sCD163 in deterioration group was in-creased ,according to time reducing .Conclusion :The overexpression of sCD163 may be involved in the occurrence and development of sepsis in children ,which might be used as a mark to estimate the degree of differentiation or prognosis of sepsis .