陕西医学杂志
陝西醫學雜誌
협서의학잡지
SHAANXI MEDICAL JOURNAL
2013年
11期
1495-1497
,共3页
麻醉和镇痛%氟比洛芬酯%镇痛药 ,阿片类/治疗应用%妇科外科手术
痳醉和鎮痛%氟比洛芬酯%鎮痛藥 ,阿片類/治療應用%婦科外科手術
마취화진통%불비락분지%진통약 ,아편류/치료응용%부과외과수술
Anesthesia and analgesia%Flurbiprofen axetils%Analgesics opioids/therapeutic uses%Gynecological surgical procedures
目的：观察氟比洛芬酯复合阿片类药物用于妇科开腹术后静脉自控镇痛的临床效果及对比研究。方法：选择妇科行开腹手术患者90例，随机分为三组，每组30例。布托啡诺组（B组）持续量：布托啡诺6mg＋氟比洛芬酯90mg＋托烷司琼6mg＋生理盐水至100ml；吗啡组（M 组）持续量：吗啡30mg＋氟比洛芬酯90mg＋托烷司琼6mg＋生理盐水至100ml；氟比洛芬酯组（F组）持续量：氟比洛芬酯120mg＋托烷司琼6mg＋生理盐水至100ml ，三组患者术毕时均静脉注射氟比洛芬酯60mg作为负荷剂量，然后连接PCIA泵。术后6、12、24、48h监测HR、MAP、RR和sPO2，分别于术后6、12、24、48h记录镇痛评分（VAS评分）、PCA按压次数、恶心呕吐评分、瘙痒评分及呼吸抑制等不良反应。结果：三组患者V A S评分：布托啡诺组（B组）和吗啡组（M 组）与氟比洛芬酯组（F组）相比有统计学差异，布托啡诺组（B组）和吗啡组（M 组）镇痛效果优于氟比洛芬酯组（F组）；布托啡诺组（B组）与吗啡组（M 组）镇痛效果比较无统计学差异。不良反应发生情况：恶心呕吐与皮肤瘙痒评分均显示，布托啡诺组（B组）和氟比洛芬酯组（F组）明显低于吗啡组（M 组），布托啡诺组（B组）与氟比洛芬酯组（F组）相比无统计学差异。结论：氟比洛芬酯复合布托啡诺用于妇科开腹术后镇痛效果确切，恶心呕吐、皮肤瘙痒、呼吸抑制等副作用发生率低，更适用于妇科开腹术后静脉自控镇痛。
目的：觀察氟比洛芬酯複閤阿片類藥物用于婦科開腹術後靜脈自控鎮痛的臨床效果及對比研究。方法：選擇婦科行開腹手術患者90例，隨機分為三組，每組30例。佈託啡諾組（B組）持續量：佈託啡諾6mg＋氟比洛芬酯90mg＋託烷司瓊6mg＋生理鹽水至100ml；嗎啡組（M 組）持續量：嗎啡30mg＋氟比洛芬酯90mg＋託烷司瓊6mg＋生理鹽水至100ml；氟比洛芬酯組（F組）持續量：氟比洛芬酯120mg＋託烷司瓊6mg＋生理鹽水至100ml ，三組患者術畢時均靜脈註射氟比洛芬酯60mg作為負荷劑量，然後連接PCIA泵。術後6、12、24、48h鑑測HR、MAP、RR和sPO2，分彆于術後6、12、24、48h記錄鎮痛評分（VAS評分）、PCA按壓次數、噁心嘔吐評分、瘙癢評分及呼吸抑製等不良反應。結果：三組患者V A S評分：佈託啡諾組（B組）和嗎啡組（M 組）與氟比洛芬酯組（F組）相比有統計學差異，佈託啡諾組（B組）和嗎啡組（M 組）鎮痛效果優于氟比洛芬酯組（F組）；佈託啡諾組（B組）與嗎啡組（M 組）鎮痛效果比較無統計學差異。不良反應髮生情況：噁心嘔吐與皮膚瘙癢評分均顯示，佈託啡諾組（B組）和氟比洛芬酯組（F組）明顯低于嗎啡組（M 組），佈託啡諾組（B組）與氟比洛芬酯組（F組）相比無統計學差異。結論：氟比洛芬酯複閤佈託啡諾用于婦科開腹術後鎮痛效果確切，噁心嘔吐、皮膚瘙癢、呼吸抑製等副作用髮生率低，更適用于婦科開腹術後靜脈自控鎮痛。
목적：관찰불비락분지복합아편류약물용우부과개복술후정맥자공진통적림상효과급대비연구。방법：선택부과행개복수술환자90례，수궤분위삼조，매조30례。포탁배낙조（B조）지속량：포탁배낙6mg＋불비락분지90mg＋탁완사경6mg＋생리염수지100ml；마배조（M 조）지속량：마배30mg＋불비락분지90mg＋탁완사경6mg＋생리염수지100ml；불비락분지조（F조）지속량：불비락분지120mg＋탁완사경6mg＋생리염수지100ml ，삼조환자술필시균정맥주사불비락분지60mg작위부하제량，연후련접PCIA빙。술후6、12、24、48h감측HR、MAP、RR화sPO2，분별우술후6、12、24、48h기록진통평분（VAS평분）、PCA안압차수、악심구토평분、소양평분급호흡억제등불량반응。결과：삼조환자V A S평분：포탁배낙조（B조）화마배조（M 조）여불비락분지조（F조）상비유통계학차이，포탁배낙조（B조）화마배조（M 조）진통효과우우불비락분지조（F조）；포탁배낙조（B조）여마배조（M 조）진통효과비교무통계학차이。불량반응발생정황：악심구토여피부소양평분균현시，포탁배낙조（B조）화불비락분지조（F조）명현저우마배조（M 조），포탁배낙조（B조）여불비락분지조（F조）상비무통계학차이。결론：불비락분지복합포탁배낙용우부과개복술후진통효과학절，악심구토、피부소양、호흡억제등부작용발생솔저，경괄용우부과개복술후정맥자공진통。
Objects :The observed the flurbiprofen axetil composite opioids for controlled analgesia after gynecological laparotomy clinical efficiency and comparative study .Method:Select Chang’an Hospital gynecological surgery Randomly divided into three groups ,Butorphanol group (B ) ,sustained amount :butorphanol 6mg + flur-biprofen axetil The 90mg + tropisetron 6mg to 100ml ,load amount :butorphanol 1mg to 5ml;Morphine group (M group ) ,Sustained amount :morphine 30mg + flurbiprofen axetil 90mg + tropisetron 6mg to 100ml ,morphine 5mg loading dose :To 5ml;The flurbiprofen axetil group (F group) ,sustained amount :flurbiprofen axetil 120mg+ tropisetron 6mg To 100ml ,the three groups of patients who were intravenous flubiprofen ester 60mg dose as a load ,then connect the PCIA pump .6 ,12 ,24 and 48 hours after surgery to monitor HR ,BP ,RR and sPO2 ,6 ,12 , 24 and 48 hours respectively after record pain scores ,PCA pressing times rated Adverse reactions of nausea and vomiting score ,pruritus score and respiratory depression .Result :Three groups of the analgesic rated using a visual analog scale:6 ,12 ,24 and 48 hours after the butorphanol group and morphine group and flurbiprofen axetil group significant difference ,butorphanol group and the analgesic effect of morphine group was superior to the flurbiprofen axetil group .Butorphanol group and the analgesic effect of morphine group no significant difference .Adverse reac-tions occur :nausea and vomiting and skin pruritus score were shown :butorphanol group and flurbiprofen axetil group ,significantly lower than morphine group ,butorphanol group ,and fluorine than the ibuprofen ester group there was no significant difference .Conclusion:Exact butorphanol flurbiprofen axetil for gynecological laparotomy postoperative analgesic effect ,nausea ,vomiting ,skin itching ,respiratory depression ,a low incidence of side effects ,and more suitable for gynecological laparotomy postoperative intravenous analgesia .
