CAJ | 학술논문

目的：探讨各型老年期痴呆患者血浆同型半胱氨酸（ Hcy ）水平变化特点。方法采用放射免疫比浊法测定阿尔茨海默病（AD）42例、血管性痴呆（VD）40例、帕金森痴呆（PDD）33例及对照组50例，空腹血浆Hcy及血管紧张素转化酶水平。结果 PDD组血浆Hcy水平低于VD组、AD组、对照组（ P＜0．05），而血管紧张素转化酶水平高于VD组、AD组、对照组（ P＜0．05）；VD组、AD组、对照组的Hcy水平及血管紧张素转化酶水平比较差异均无统计学意义（ P＞0．05）。结论可能血浆Hcy水平与稳定期老年性痴呆无关联。
목적：탐토각형노년기치태환자혈장동형반광안산（ Hcy ）수평변화특점。방법채용방사면역비탁법측정아이자해묵병（AD）42례、혈관성치태（VD）40례、파금삼치태（PDD）33례급대조조50례，공복혈장Hcy급혈관긴장소전화매수평。결과 PDD조혈장Hcy수평저우VD조、AD조、대조조（ P＜0．05），이혈관긴장소전화매수평고우VD조、AD조、대조조（ P＜0．05）；VD조、AD조、대조조적Hcy수평급혈관긴장소전화매수평비교차이균무통계학의의（ P＞0．05）。결론가능혈장Hcy수평여은정기노년성치태무관련。
Objective To investigate the changes of plasma homocysteine ( Hcy ) levels among patients with various types of dementia .Methods Fasting plasma Hcy and angiotensin converting enzyme levels were respectively measured in 42 patients with Alzheimer′s disease(AD),40 patients with vascular dementia (VD),33 patients with Parkinson′s dementia ( PDD ) and 50 cases of the control with immunoturbidimetry .Results The levels of plasma Hcy in PDD group were significantly lower than those in VD group ,AD group and the control(P<0.05),while the levels of angiotensin converting enzyme in PDD group were significantly higher than those in VD group ,AD group and the control(P<0.05).There was no significant difference in the Hcy and angiotensin converting enzyme levels a -mong AD group,VD group and the control(P>0.05).Conclusion The levels of plasma Hcy might not be associat-ed with senile dementia during the stable period .