广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2014年
11期
64-65
,共2页
氨磷汀%细胞保护剂%合成
氨燐汀%細胞保護劑%閤成
안린정%세포보호제%합성
amifostine%cytoprotector%synthesis
以2-羟基乙胺为原料，与丙烯腈反应后经还原、溴代、成盐、精制得细胞保护剂氨磷汀，中间体及终产物结构经红外、氢谱确证，并通过HPLC与终产物标准品对照测得其纯度。新的工艺对各步反应进行了优化，收率达37.3％，纯度达99.2％。
以2-羥基乙胺為原料，與丙烯腈反應後經還原、溴代、成鹽、精製得細胞保護劑氨燐汀，中間體及終產物結構經紅外、氫譜確證，併通過HPLC與終產物標準品對照測得其純度。新的工藝對各步反應進行瞭優化，收率達37.3％，純度達99.2％。
이2-간기을알위원료，여병희정반응후경환원、추대、성염、정제득세포보호제안린정，중간체급종산물결구경홍외、경보학증，병통과HPLC여종산물표준품대조측득기순도。신적공예대각보반응진행료우화，수솔체37.3％，순도체99.2％。
Amifostine , a cytoprotector , was synthesized by reaction of 2 -Aminoethanol with acrylonitrile and via condensation, bromination, salification, and purified.The structures of the intermediates and final product were characterized by IR and 1 HNMR, and the purity was measured via HPLC by contrast with standard substance.By optimizing each step , the total yield was raised to 37.3%and purity of 99.2%.
