CAJ | 학술논문

以异噁唑为原料，经碱性开环、亲核加成、成环脱羧、 Clauson-Kaas四步反应合成了1′，3-联吡咯-2-羧酸乙酯，其结构经1 H-NMR确认。由于本方法中异噁唑碱性开环与加成两步反应实现一锅法，并对脱羧成环及Clauson-Kaas反应条件进行了优化，简化了工艺操作，降低了分离难度，提高了收率和产品纯度，适用于公斤级生产。
이이오서위원료，경감성개배、친핵가성、성배탈최、 Clauson-Kaas사보반응합성료1′，3-련필각-2-최산을지，기결구경1 H-NMR학인。유우본방법중이오서감성개배여가성량보반응실현일과법，병대탈최성배급Clauson-Kaas반응조건진행료우화，간화료공예조작，강저료분리난도，제고료수솔화산품순도，괄용우공근급생산。
1H-[1′,3 -bipyrrole] -2 -carboxylate was synthesized from isodaxale by employing four steps of reaction with base -catalyzed ring opening , nucleophilic addition , decarboxylation -cyclization and Clauson -Kaas reaction.Structure of the products was characterized by 1 H-NMR.Since base-catalyzed ring opening of isoxazole and the nucleophilic addition was achieved in a one -pot procedure , reaction conditions of decarboxylation -cyclization and Clauson-Kaas reaction were optimized , the synthetic and isolation process was simplified , and yield and purity were increased , which was suitable for large -scale production.