CAJ | 학술논문

建立了气相色谱法测定福辛普利钠中异辛酸和新戊酸的残留量。采用DB-wax （50 m ×0.32 mm，3μm）色谱柱， FID检测，以氮气为载气，起始温度50℃，保持5 min后，以40℃/min的速度升至170℃，保持10 min，以甲醇为稀释液，正戊酸为内标物，直接进样。结果显示，福辛普利钠中异辛酸和新戊酸完全分开，浓度在考察范围内与峰面积具有良好的线性关系，相关系数r为0.9994和0.9991，精密度RSD均小于10％，平均回收率分别为98.9％、97.8％均在90％～110％之间。本法快速、灵敏、准确，可用于福辛普利钠中异辛酸和新戊酸的测定。
건립료기상색보법측정복신보리납중이신산화신무산적잔류량。채용DB-wax （50 m ×0.32 mm，3μm）색보주， FID검측，이담기위재기，기시온도50℃，보지5 min후，이40℃/min적속도승지170℃，보지10 min，이갑순위희석액，정무산위내표물，직접진양。결과현시，복신보리납중이신산화신무산완전분개，농도재고찰범위내여봉면적구유량호적선성관계，상관계수r위0.9994화0.9991，정밀도RSD균소우10％，평균회수솔분별위98.9％、97.8％균재90％～110％지간。본법쾌속、령민、준학，가용우복신보리납중이신산화신무산적측정。
The DB -WAX capillary column was used to establish a QC method for the determination of 2 -Ethylhexanoic acid and pivalic acid in Fosinopril sodium.The detector was FID , the carrier gas was nitrogen , column temperature was maintained at 40 ℃for 10 min, then increased to 170 at 40 ℃/min maintained at 120 ℃ for 10 min, dilution in methanol , internal standard substances of Valeric acid , direct injection.The results showed that the detected solvents (2 -Ethylhexanoic acid and pivalic acid ) were separated completely , the calibration curve of each solvent showed a good linear relationship ( R was 0.999 4 and 0.999 1 ) precision RSD were less than 10%.The average recovery rate was 98.9%、 97.8%in the range of 90%~110%.The established method was rapid , sensitive , and can be used to determine the 2-Ethylhexanoic acid and pivalic acid of Fosinopril sodium.