新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
6期
737-739
,共3页
阿合力·那斯肉拉%那·那芹%阿衣古丽·哈热
阿閤力·那斯肉拉%那·那芹%阿衣古麗·哈熱
아합력·나사육랍%나·나근%아의고려·합열
食管癌%放射治疗%化学治疗%替吉奥%5-氟尿嘧啶
食管癌%放射治療%化學治療%替吉奧%5-氟尿嘧啶
식관암%방사치료%화학치료%체길오%5-불뇨밀정
esophagus cancer%S-1%radiotherapy%chemotherapy%fluorouracil
目的：探讨替吉奥与单药氟尿嘧啶加同步放疗治疗中晚期食管癌的近期临床疗效。方法将66例中晚期食管癌患者随机分为两组，替吉奥胶囊口服＋同步放疗组（试验组）38例，单药氟尿嘧啶静点＋同步放疗组（对照组）28例，放疗方案均采用食管病灶区适形调强放射治疗（intensity modulated radiation therapy ），放疗剂量为60～66 Gy。观察两组临床疗效、生存情况及毒副反应。结果试验组和对照组的治疗有效率分别为894．％和893．％，差异无统计学意义（χ2＝0．012， P ＝0．996）；两组的1年、2年生存率分别为86．1％、64．1％和76．9％、419．％，差异无统计学意义；两组总的生存率比较差异无统计学意义（χ2＝07．55， P ＝00．97）；两组均无严重的放射性食管炎（3～4级）及血液学毒副反应（Ⅳ°）的发生。结论替吉奥联合放射治疗中晚期食管癌有较好的近期疗效，且毒副反应可耐受。
目的：探討替吉奧與單藥氟尿嘧啶加同步放療治療中晚期食管癌的近期臨床療效。方法將66例中晚期食管癌患者隨機分為兩組，替吉奧膠囊口服＋同步放療組（試驗組）38例，單藥氟尿嘧啶靜點＋同步放療組（對照組）28例，放療方案均採用食管病竈區適形調彊放射治療（intensity modulated radiation therapy ），放療劑量為60～66 Gy。觀察兩組臨床療效、生存情況及毒副反應。結果試驗組和對照組的治療有效率分彆為894．％和893．％，差異無統計學意義（χ2＝0．012， P ＝0．996）；兩組的1年、2年生存率分彆為86．1％、64．1％和76．9％、419．％，差異無統計學意義；兩組總的生存率比較差異無統計學意義（χ2＝07．55， P ＝00．97）；兩組均無嚴重的放射性食管炎（3～4級）及血液學毒副反應（Ⅳ°）的髮生。結論替吉奧聯閤放射治療中晚期食管癌有較好的近期療效，且毒副反應可耐受。
목적：탐토체길오여단약불뇨밀정가동보방료치료중만기식관암적근기림상료효。방법장66례중만기식관암환자수궤분위량조，체길오효낭구복＋동보방료조（시험조）38례，단약불뇨밀정정점＋동보방료조（대조조）28례，방료방안균채용식관병조구괄형조강방사치료（intensity modulated radiation therapy ），방료제량위60～66 Gy。관찰량조림상료효、생존정황급독부반응。결과시험조화대조조적치료유효솔분별위894．％화893．％，차이무통계학의의（χ2＝0．012， P ＝0．996）；량조적1년、2년생존솔분별위86．1％、64．1％화76．9％、419．％，차이무통계학의의；량조총적생존솔비교차이무통계학의의（χ2＝07．55， P ＝00．97）；량조균무엄중적방사성식관염（3～4급）급혈액학독부반응（Ⅳ°）적발생。결론체길오연합방사치료중만기식관암유교호적근기료효，차독부반응가내수。
Objective To evaluate the efficacy and survival rate and side reaction of S-1 combined with con-current radiotherapy in the treatment of advanced esophageal cancer .Methods 66 patients with advanced squamous cell carcinoma of the esophagus were divided into two groups :the experimental group (38 cases) and the control group (28 cases) .The radiotherapy regimens was intensity modulated radiation therapy (IMRT) ,the radiotherapy dosage was 60 -66 Gy .Then we observed the therapeutic effect and side effect of the two groups after the treatment .Results The overall response rate (CR+PR) of the ex-perimental group and the control group were 89 4.% and 89 3.% respectively (P >0 0.5) .The one-year and two-year survival rates of S-1 chemoradiotherapy group and Fluorouracil chemoradiotherapy group were 86 1.% ,64 1.% and 76 9.% ,41 9.% ,and the difference was not statistically significant (P >0 0.5) .Serious side effects ,including marrow depression and radioactive esophagitis ,did not occur in both groups .Con-clusion The curative effect of concurrent radiochemotherapy in locally advanced esophageal cancer is better than that of radiotherapy only ,and will not elicit the serious adverse reaction .The short term cura-tive effect of S-1 and Fluorouracil in combination with radiotherapy is feasible for medium and terminal e-sophageal cancer ,and toxicity is tolerable .
