上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2013年
21期
51-53
,共3页
刘文丽%韩海岭%韩建生
劉文麗%韓海嶺%韓建生
류문려%한해령%한건생
肠溶%微粒%阿司匹林%包衣
腸溶%微粒%阿司匹林%包衣
장용%미립%아사필림%포의
delayed release%particle%aspirin%coating
目的：研制阿司匹林多单元肠溶微丸片。方法：采用阿司匹林粉末包衣先制备肠溶包衣微粒，再与适量辅料混合后直接压片制备肠溶阿司匹林微粒片，并对影响其质量的关键因素进行了考察。结果：制备的微粒片溶出度符合阿司匹林肠溶制剂质量的标准要求。
目的：研製阿司匹林多單元腸溶微汍片。方法：採用阿司匹林粉末包衣先製備腸溶包衣微粒，再與適量輔料混閤後直接壓片製備腸溶阿司匹林微粒片，併對影響其質量的關鍵因素進行瞭攷察。結果：製備的微粒片溶齣度符閤阿司匹林腸溶製劑質量的標準要求。
목적：연제아사필림다단원장용미환편。방법：채용아사필림분말포의선제비장용포의미립，재여괄량보료혼합후직접압편제비장용아사필림미립편，병대영향기질량적관건인소진행료고찰。결과：제비적미립편용출도부합아사필림장용제제질량적표준요구。
Objective:To prepare multi-unit tablets of delayed release aspirin. Methods:Delayed release particle was made by aspirin powder coating technology, to which coated particles was mixed with other excipient and then direct compress was used to make multiple particle tablets. Meanwhile some important factors affecting product quality were studied. Results:Release proifle of this multi-unit tablets complies to the speciifcation of delayed release aspirin.
