CAJ | 학술논문

目的：研究蛇肽保健酒对小鼠佐剂性关节炎（A A ）的影响。方法将健康雄性昆明种小鼠随机分为6组，即对照组、模型组、阳性对照组（1 mg/kg地塞米松）、酒基组（10 mL/kg ）、蛇肽保健酒低剂量组（8．3 mL/kg ）和高剂量组（33．2 mL/kg ）；每隔7 d分别测定小鼠右后足趾、踝关节直径和体质量，实验第34天处死小鼠，进行脾脏指数、血清循环免疫复合物（CIC ）水平的测定。结果蛇肽保健酒低剂量组对降低AA小鼠的血清CIC水平效果显著（P＜0．05），对降低足趾和踝关节肿胀度、脾脏指数效果均极显著（P＜0．01）。结论蛇肽保健酒对小鼠佐剂性关节炎具有抑制作用。
목적：연구사태보건주대소서좌제성관절염（A A ）적영향。방법장건강웅성곤명충소서수궤분위6조，즉대조조、모형조、양성대조조（1 mg/kg지새미송）、주기조（10 mL/kg ）、사태보건주저제량조（8．3 mL/kg ）화고제량조（33．2 mL/kg ）；매격7 d분별측정소서우후족지、과관절직경화체질량，실험제34천처사소서，진행비장지수、혈청순배면역복합물（CIC ）수평적측정。결과사태보건주저제량조대강저AA소서적혈청CIC수평효과현저（P＜0．05），대강저족지화과관절종창도、비장지수효과균겁현저（P＜0．01）。결론사태보건주대소서좌제성관절염구유억제작용。
Objective To investigate effect of the venom peptide liquor on adjunctive arthritis (AA) in mice .Methods The male Kunming mice were randomly divided into 6 groups ,named as the control group ,model group ,positive control group(1 mg/kg dex-amethason) ,wine group(10 mL/kg) ,low dosage of venom peptide liquor group(8 .3 mL/kg) and high dosage of venom peptide liq-uor group(33 .2 mL/kg);the right toes ,ankle diameter and whole body weight were measured at 7-day intervals ;the spleen index , serum level of circulating immune complexes(CIC) were determined after the thirty-fourth day when the mice was put to death .Re-sults The level of CIC in AA mice decreased significantly (P<0 .05) ,the decrease of spleen index and the reduction of toe and an-kle swelling in the low dose group were significant(P<0 .01) .Conclusion The venom peptide liquor exhibited apparent inhibitory effect on AA in mice .