CAJ | 학술논문

目的：分析氟伐他汀对骨质疏松大鼠血清雌二醇（E2）、肿瘤坏死因子-α（TNF-α）、胰岛素样生长因子-1（IGF-1）；及血清骨钙素（BGP）水平的影响。方法采用去势法复制骨质疏松大鼠动物模型，同时给予不同剂量的氟伐他汀（20、10、5mg/kg）进行干预，12周后，大鼠称重后处死，摘取子宫称湿重，计算子宫指数，同时取血清测定E2、TNF-α、IGF-1及BGP的浓度。结果氟伐他汀各给药组对骨质疏松大鼠子宫重量无影响；氟伐他汀20mg/kg可使骨质疏松大鼠血清E2、IGF-1水平升高（P＜0．05），TNF-α及BGP水平降低（P＜0．01）；氟伐他汀10mg/kg可使骨质疏松大鼠BGP水平下降。结论氟伐他汀可升高骨质疏松大鼠血清E2、IGF-1水平，并降低TNF-a及BGP。
목적：분석불벌타정대골질소송대서혈청자이순（E2）、종류배사인자-α（TNF-α）、이도소양생장인자-1（IGF-1）；급혈청골개소（BGP）수평적영향。방법채용거세법복제골질소송대서동물모형，동시급여불동제량적불벌타정（20、10、5mg/kg）진행간예，12주후，대서칭중후처사，적취자궁칭습중，계산자궁지수，동시취혈청측정E2、TNF-α、IGF-1급BGP적농도。결과불벌타정각급약조대골질소송대서자궁중량무영향；불벌타정20mg/kg가사골질소송대서혈청E2、IGF-1수평승고（P＜0．05），TNF-α급BGP수평강저（P＜0．01）；불벌타정10mg/kg가사골질소송대서BGP수평하강。결론불벌타정가승고골질소송대서혈청E2、IGF-1수평，병강저TNF-a급BGP。
Objective To investigate the effects of fluvastatin (Flu) on the levels of estradiol(E2 ) ,tumor necrosis factor-α(TNF-α) ,insulin-like growth factor-1(IGF-1) and bone glaprotein(BGP) in experimental osteoporosis rats .Methods The model of osteo-porosis was established ,all rats were ovariectomized .The rats were given Flu(20 ,10 ,5 mg/kg) through intragastric administration (ig) .After treating for 12 weeks ,weighed all rats ,then sacrificed all rats ,removed the uterus and weighed its wet weight ,and calcu-lated uterus index ;the levels of E2 ,TNF-α,IGF-1 and BGP in serum were detected .Results Flu did not affect the uterus weight in experimental osteoporosis rats ;20 mg/kg Flu could increased the osteoporosis rat′s serum levels of E2 and IGF-1(P<0 .05) ,de-creased the levels of TNF-αand BGP(P<0 .01);10 mg/kg Flu could decreased the osteoporosis rat′s serum levels of BGP .Conclu-sion Flu could increased the levels of E2 ,IGF-1 ,and decreased the levels of TNF-α,BGP in experimental osteoporosis rats .