中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
30期
9-11
,共3页
2型糖尿病%冠状动脉造影%动脉粥样硬化%高尿酸血症%危险因素
2型糖尿病%冠狀動脈造影%動脈粥樣硬化%高尿痠血癥%危險因素
2형당뇨병%관상동맥조영%동맥죽양경화%고뇨산혈증%위험인소
Type 2 diabetes mellitus%Coronary angiography%Atherosclerosis%Hyperuricemia%Risk factors
目的:探讨糖尿病患者血脂谱与尿酸代谢特点并寻找冠状动脉粥样硬化病变的独立危险因素。方法回顾性分析2012年1月至2013年4月在我院住院的422例接受CAG检查患者临床资料,其中66例合并2型糖尿病纳入糖尿病组,356例无糖尿病归为对照组。根据CAG结果分为冠状动脉正常组(B组),单支病变(A1组)、双支病变(A2组)、多支病变组(A3组)。测定各组血清尿酸、血脂、空腹血糖、糖化血红蛋白水平。结果糖尿病组与对照组相比,年龄、性别、血清TC、LDL及HDL水平无明显差异(P>0.05),血清UA、TG、FBS、HbA1c均较对照组升高(P<0.05)。糖尿病组合并高血压病、高三酰甘油血症及高尿酸血症比例均较对照组显著增高(P<0.01)。Spearman秩相关分析显示冠状动脉粥样硬化病变程度与糖尿病相关(P=0.001),糖尿病组冠状动脉病变更弥漫。二项分类Logistic回归分析显示男性(OR=2.421,95%CI1.576~3.718,P=0.000)、高三酰甘油血症(OR=1.749,95%CI1.071~2.856,P=0.025)及高尿酸血症(OR=1.719,95%CI1.076~2.744,P=0.023)均为冠状动脉粥样硬化病变的独立危险因素。结论糖尿病患者合并高血压病、血脂代谢紊乱、高尿酸血症发生率较非糖尿病患者高,冠状动脉粥样硬化病变更弥漫,男性、高三酰甘油血症及高尿酸血症均为冠状动脉粥样硬化病变的独立危险因素。
目的:探討糖尿病患者血脂譜與尿痠代謝特點併尋找冠狀動脈粥樣硬化病變的獨立危險因素。方法迴顧性分析2012年1月至2013年4月在我院住院的422例接受CAG檢查患者臨床資料,其中66例閤併2型糖尿病納入糖尿病組,356例無糖尿病歸為對照組。根據CAG結果分為冠狀動脈正常組(B組),單支病變(A1組)、雙支病變(A2組)、多支病變組(A3組)。測定各組血清尿痠、血脂、空腹血糖、糖化血紅蛋白水平。結果糖尿病組與對照組相比,年齡、性彆、血清TC、LDL及HDL水平無明顯差異(P>0.05),血清UA、TG、FBS、HbA1c均較對照組升高(P<0.05)。糖尿病組閤併高血壓病、高三酰甘油血癥及高尿痠血癥比例均較對照組顯著增高(P<0.01)。Spearman秩相關分析顯示冠狀動脈粥樣硬化病變程度與糖尿病相關(P=0.001),糖尿病組冠狀動脈病變更瀰漫。二項分類Logistic迴歸分析顯示男性(OR=2.421,95%CI1.576~3.718,P=0.000)、高三酰甘油血癥(OR=1.749,95%CI1.071~2.856,P=0.025)及高尿痠血癥(OR=1.719,95%CI1.076~2.744,P=0.023)均為冠狀動脈粥樣硬化病變的獨立危險因素。結論糖尿病患者閤併高血壓病、血脂代謝紊亂、高尿痠血癥髮生率較非糖尿病患者高,冠狀動脈粥樣硬化病變更瀰漫,男性、高三酰甘油血癥及高尿痠血癥均為冠狀動脈粥樣硬化病變的獨立危險因素。
목적:탐토당뇨병환자혈지보여뇨산대사특점병심조관상동맥죽양경화병변적독립위험인소。방법회고성분석2012년1월지2013년4월재아원주원적422례접수CAG검사환자림상자료,기중66례합병2형당뇨병납입당뇨병조,356례무당뇨병귀위대조조。근거CAG결과분위관상동맥정상조(B조),단지병변(A1조)、쌍지병변(A2조)、다지병변조(A3조)。측정각조혈청뇨산、혈지、공복혈당、당화혈홍단백수평。결과당뇨병조여대조조상비,년령、성별、혈청TC、LDL급HDL수평무명현차이(P>0.05),혈청UA、TG、FBS、HbA1c균교대조조승고(P<0.05)。당뇨병조합병고혈압병、고삼선감유혈증급고뇨산혈증비례균교대조조현저증고(P<0.01)。Spearman질상관분석현시관상동맥죽양경화병변정도여당뇨병상관(P=0.001),당뇨병조관상동맥병변경미만。이항분류Logistic회귀분석현시남성(OR=2.421,95%CI1.576~3.718,P=0.000)、고삼선감유혈증(OR=1.749,95%CI1.071~2.856,P=0.025)급고뇨산혈증(OR=1.719,95%CI1.076~2.744,P=0.023)균위관상동맥죽양경화병변적독립위험인소。결론당뇨병환자합병고혈압병、혈지대사문란、고뇨산혈증발생솔교비당뇨병환자고,관상동맥죽양경화병변경미만,남성、고삼선감유혈증급고뇨산혈증균위관상동맥죽양경화병변적독립위험인소。
Objective The incidence and prevalence of type 2 diabetes mellitus continue to escalate globally at alarming rates. Our study aim to investigate the lipid proifle components and uric acid in patients with type 2 diabetes and to ifnd out coronary atherosclerosis independent risk factors. Methods This observational cohort study recruited for 422 patients hospitalized from January 2012 to April 2013 underwent coronary angiography(CAG) .There were 66 cases of T2DM and 356 cases of normal glucose tolerance were divided into 4 groups according to CAG,B group:Non-CAD, A1 group:one diseased branche arterial, A2 group:double vessel lesions,A3 group:several diseased branches arterial.All biochemical analysis were assessed by local laboratories using standard laboratory methods. Results No significant difference of age, sex, serum total cholesterol, low-density lipoprotein and high-density lipoprotein was observed between the control group and diabetes group(P>0.05), while the serum uric acid level, triglyceride,fasting blood-glucose and hemoglobin A1c of diabetes group were signiifcantly higher than that of control group(P<0.05). The incidence of hypertension , hypertriglyceridemia and hyperuricemia was markedly higher of diabetes group than that of control group(P<0.01) . The degree of coronary atherosclerosis was positively correlated with diabetes(P=0.001), coronary atherosclerosis lesions were more diffuse in diabetes group . In binary logistic regression analysis, we found that male(OR=2.421, 95%CI1.576~3.718, P=0.000), hypertriglyceridemia(OR=1.749, 95%CI1.071~2.856, P=0.025)and hyperuricemia (OR=1.719, 95%CI1.076~2.744, P=0.023)were independent risk factors for coronary atherosclerosis. Conclusions Hypertension, hypertriglyceridemia and hyperuricemia are more common and coronary atherosclerosis lesions were more diffuse in patients with T2DM.Male, hypertriglyceridemia and hyperuricemia were independent risk factors for coronary atherosclerosis .