CAJ | 학술논문

目的：通过比较首发和复发双相情感障碍患者生活质量和治疗成本，为早期干预提供依据。方法对50例首发和50例复发双相情感障碍患者在入组后第3、6、9、12个月进行生活质量、疾病治疗的直接成本及间接成本的随访。以贝克-拉范森躁狂量表（BRMS-11）汉密尔顿抑郁量表17项（HAMD-17）和健康状况调查问卷（SF-36）分别评定患者疗效，随访12个月进行两组的生活质量与经济成本比较。结果①首发组SF-36躯体功能和躯体疼痛情况好于复发组（P＜0.05），其他因子两组无明显差异（P＞0.05）；②复发组的总成本绝对值、间接成本绝对值及间接成本所占比例均高于首发组（P＜0.01）。结论双相情感障碍的复发患者与首发患者相比，生活质量和治疗花费成本更多。
목적：통과비교수발화복발쌍상정감장애환자생활질량화치료성본，위조기간예제공의거。방법대50례수발화50례복발쌍상정감장애환자재입조후제3、6、9、12개월진행생활질량、질병치료적직접성본급간접성본적수방。이패극-랍범삼조광량표（BRMS-11）한밀이돈억욱량표17항（HAMD-17）화건강상황조사문권（SF-36）분별평정환자료효，수방12개월진행량조적생활질량여경제성본비교。결과①수발조SF-36구체공능화구체동통정황호우복발조（P＜0.05），기타인자량조무명현차이（P＞0.05）；②복발조적총성본절대치、간접성본절대치급간접성본소점비례균고우수발조（P＜0.01）。결론쌍상정감장애적복발환자여수발환자상비，생활질량화치료화비성본경다。
Objective To compare life quality and health costs in ifrst-episode and recurrent outpatients with bipoiar disorder, thus providing evidence for early intervention. Methods 50 ifrst-episode and 50 recurrent outpatients with bipoiar disorder were recruited and life quality, direct and indirect health related costs were evaluated at the 3rd, 6th, 9th and 12th month. The clinical status and life quality of patients were assessed using Bech-Rafaelsdn Mania Rating Scale(BRMS-1),Hamilton depression scale-17 items (HAMD-17) and the Short-form-36 than health survey(SF-36). Result ①First-episode patients had better physical function and less physical pain in SF-36 than recurrent ones (P<0.05),while no difference were found for other SF-36 factors(P>0.05).②Total costs, indirect health-related costs, and proportion of indirect costs but not direct costs were higher in the recurrent group than in the ifrst-episode group(P<0.01).Costs of effectiveness ratios were much higher in the recurrent group than that in the ifrst-episode group in terms of costs of unit decrease in HAMD-17 or unit increase in SF-36. Conclusions Patients with recurrent bipoiar disorder intend to have more severe impairment of quality of life, less productivity and higher health costs.