临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
4期
343-345
,共3页
金伶%龙兴江%袁大华%杨彤%黄献文
金伶%龍興江%袁大華%楊彤%黃獻文
금령%룡흥강%원대화%양동%황헌문
脾切除%地中海贫血%铁负荷%血清铁蛋白%儿童
脾切除%地中海貧血%鐵負荷%血清鐵蛋白%兒童
비절제%지중해빈혈%철부하%혈청철단백%인동
splenectomy%thalassemia%iron overload%serum ferritin%child
目的：探讨重度β-地中海贫血患儿脾脏切除术前后铁负荷状况的变化。方法回顾性分析2003年1月至2012年12月18例重度β-地中海贫血患儿行脾切除术前、后的年输血量及血清铁蛋白水平。结果重度β-地中海贫血患儿脾切除术后第1年和第2年的平均年输血量为（101.94±30.73）ml/kg和（96.50±34.00）ml/kg，均分别低于脾切除术前2年（241.89±73.66）ml/kg和前1年（289.22±102.30）ml/kg的年输血量，差异均有统计学意义（P<0.05）。脾切除术后6、12、18和24个月患儿的血清铁蛋白（SF）水平分别为（2410.00±731.77）μg/L、（2742.78±813.74）μg/L、（2870.56±740.94）μg/L和（2886.67±795.34）μg/L，均低于脾切除术前SF水平[（4975.00±1245.85）μg/L]，差异均有统计学意义（P<0.05）。结论行脾切除术后β-地中海贫血患儿血清铁蛋白水平较前降低，但仍远高于正常值，需持续监测及去铁治疗。
目的：探討重度β-地中海貧血患兒脾髒切除術前後鐵負荷狀況的變化。方法迴顧性分析2003年1月至2012年12月18例重度β-地中海貧血患兒行脾切除術前、後的年輸血量及血清鐵蛋白水平。結果重度β-地中海貧血患兒脾切除術後第1年和第2年的平均年輸血量為（101.94±30.73）ml/kg和（96.50±34.00）ml/kg，均分彆低于脾切除術前2年（241.89±73.66）ml/kg和前1年（289.22±102.30）ml/kg的年輸血量，差異均有統計學意義（P<0.05）。脾切除術後6、12、18和24箇月患兒的血清鐵蛋白（SF）水平分彆為（2410.00±731.77）μg/L、（2742.78±813.74）μg/L、（2870.56±740.94）μg/L和（2886.67±795.34）μg/L，均低于脾切除術前SF水平[（4975.00±1245.85）μg/L]，差異均有統計學意義（P<0.05）。結論行脾切除術後β-地中海貧血患兒血清鐵蛋白水平較前降低，但仍遠高于正常值，需持續鑑測及去鐵治療。
목적：탐토중도β-지중해빈혈환인비장절제술전후철부하상황적변화。방법회고성분석2003년1월지2012년12월18례중도β-지중해빈혈환인행비절제술전、후적년수혈량급혈청철단백수평。결과중도β-지중해빈혈환인비절제술후제1년화제2년적평균년수혈량위（101.94±30.73）ml/kg화（96.50±34.00）ml/kg，균분별저우비절제술전2년（241.89±73.66）ml/kg화전1년（289.22±102.30）ml/kg적년수혈량，차이균유통계학의의（P<0.05）。비절제술후6、12、18화24개월환인적혈청철단백（SF）수평분별위（2410.00±731.77）μg/L、（2742.78±813.74）μg/L、（2870.56±740.94）μg/L화（2886.67±795.34）μg/L，균저우비절제술전SF수평[（4975.00±1245.85）μg/L]，차이균유통계학의의（P<0.05）。결론행비절제술후β-지중해빈혈환인혈청철단백수평교전강저，단잉원고우정상치，수지속감측급거철치료。
Objective To explore the changes of iron overload in children with severeβ-thalassemia pre-and post-sple-nectomy. Method The annual amount of blood transfused and serum ferritin (SF) levels of 18 children with severeβ-thalasse-mia before and after splenectomy from January 2003 to December 2012 were retrospectively analyzed. Result The annual amount of blood transfused in children with severeβ-thalassemia at one year and two years after splenectomy were (101.94 ± 30.73) ml/kg and (96.50 ± 34.00) ml/kg respectively, significantly lower than the amount of two years before splenectomy (241.89 ± 73.66) ml/kg and one year before splenectomy (289.22 ± 102.30) ml/kg (P<0.05). The SF levels at 6, 12, 18 and 24 months after splenectomy were (2 410.00 ± 731.77) μg/L, (2 742.78 ± 813.74) μg/L, (2 870.56 ± 740.94) μg/L and (2 886.67 ± 795.34)μg/L, significantly lower than that (4 975.00±1 245.85)μg/L of before splenectomy (P<0.05). Conclusions The serum ferritin level after splenectomy significantly decreases compared with that of before splenectomy, but still remarkably higher than that of normal controls. Monitoring of serum ferritin level and iron-chelating therapy are needed.
