现代消化及介入诊疗
現代消化及介入診療
현대소화급개입진료
MODERN DIGESTION & INTERVENTION
2013年
5期
277-279,283
,共4页
屈昌民%李连勇%吴玮%王刚%尹志利%郭庆%屈昌北%曾新吾%龚昌超%田章福%柳珑
屈昌民%李連勇%吳瑋%王剛%尹誌利%郭慶%屈昌北%曾新吾%龔昌超%田章福%柳瓏
굴창민%리련용%오위%왕강%윤지리%곽경%굴창북%증신오%공창초%전장복%류롱
低频强声%大鼠%胃功能%形态学%胃动素
低頻彊聲%大鼠%胃功能%形態學%胃動素
저빈강성%대서%위공능%형태학%위동소
Strong low-frequency sound%Rats%Gastric juice pH%Gatric injury%Serum motilin
目的：探讨低频强声对大鼠胃功能及形态学的影响。方法随机将大鼠暴露于频率103 Hz或300 Hz的声场中，暴露时间分别为5 min或10 min。根据暴露的频率、作用时间，分为4个实验组和对照组。依据暴露后观察时间，每组内再分为即刻组、3天组和7天组。对低频强声暴露后大鼠行为学进行观察，测定胃液pH、胃动素水平，并对胃黏膜糜烂及组织病理学进行观察。结果低频强声暴露后大鼠活跃程度下降，反应迟钝。不同条件暴露后各组大鼠胃内pH值无明显差异，暴露3 d后胃内pH最高为3.15。所有进行检测的85例实验组大鼠胃黏膜中，有9例出现斑点糜烂，对照组6例未见明确糜烂。各组均未见明确溃疡发生。和对照组相比，各实验组尤其2、4组大鼠血清胃动素水平明显下降（P<0.05）。结论低频强声可影响大鼠的行为，并可引起急性胃黏膜损伤及胃动素水平改变。
目的：探討低頻彊聲對大鼠胃功能及形態學的影響。方法隨機將大鼠暴露于頻率103 Hz或300 Hz的聲場中，暴露時間分彆為5 min或10 min。根據暴露的頻率、作用時間，分為4箇實驗組和對照組。依據暴露後觀察時間，每組內再分為即刻組、3天組和7天組。對低頻彊聲暴露後大鼠行為學進行觀察，測定胃液pH、胃動素水平，併對胃黏膜糜爛及組織病理學進行觀察。結果低頻彊聲暴露後大鼠活躍程度下降，反應遲鈍。不同條件暴露後各組大鼠胃內pH值無明顯差異，暴露3 d後胃內pH最高為3.15。所有進行檢測的85例實驗組大鼠胃黏膜中，有9例齣現斑點糜爛，對照組6例未見明確糜爛。各組均未見明確潰瘍髮生。和對照組相比，各實驗組尤其2、4組大鼠血清胃動素水平明顯下降（P<0.05）。結論低頻彊聲可影響大鼠的行為，併可引起急性胃黏膜損傷及胃動素水平改變。
목적：탐토저빈강성대대서위공능급형태학적영향。방법수궤장대서폭로우빈솔103 Hz혹300 Hz적성장중，폭로시간분별위5 min혹10 min。근거폭로적빈솔、작용시간，분위4개실험조화대조조。의거폭로후관찰시간，매조내재분위즉각조、3천조화7천조。대저빈강성폭로후대서행위학진행관찰，측정위액pH、위동소수평，병대위점막미란급조직병이학진행관찰。결과저빈강성폭로후대서활약정도하강，반응지둔。불동조건폭로후각조대서위내pH치무명현차이，폭로3 d후위내pH최고위3.15。소유진행검측적85례실험조대서위점막중，유9례출현반점미란，대조조6례미견명학미란。각조균미견명학궤양발생。화대조조상비，각실험조우기2、4조대서혈청위동소수평명현하강（P<0.05）。결론저빈강성가영향대서적행위，병가인기급성위점막손상급위동소수평개변。
Aim To evaluate the effect of strong low-frequency sound on the behavior, gastric injury and functional change of rats. Methods The rats were exposed to a closed sound field and acousticly stimulated by strong low-frequency sound of 103 Hz or 300 Hz. The exposure time was 5 minutes or 10 minutes, respective-ly. The gastric juice pH levels, the gross and microscopic change of gastric mucosa, and the serum motilin were observed immediately, 3 days, and 7 days post-exposure. Result Reversable behavior changes occurred when the rats were exposed and stimulated by strong low-frequency sound. Gastric juice pH levels did not signifi-cantly change, while about 9%of gastric mucosa was erosive. The level of motilin was decreased after expo-sure. Conclusion The strong low-frequency sound could cause the reversible behavior change of the rats. Gastrointestinal hormone was changed when exposed in low-frequency sound. Gastric mucosa was sensitive injury target of low-frequency sound.
