CAJ | 학술논문

探讨中药复方液对麻黄素致肾组织损伤的作用．麻黄素组仔鼠用递增剂量连续腹腔注射0.2 mL浓度为2.0，3.0和4.0 g·L -1的麻黄素溶液，中药组仔鼠在注射麻黄素后分别灌胃0.2 mL浓度为20.0，30.0和40.0 g·L -1的中药复方液，分别于给药后5 d ，10 d和15 d称量检测仔鼠的体重和肾重；用比色法检测血清BUN、Cr含量的变化；用光学显微镜观察仔鼠肾组织结构的变化并测量肾小球直径的变化．结果显示麻黄素组小鼠体重均低于对照组，肾重高于对照组，肾小球直径明显大于对照组，血清BUN、Cr含量均高于对照组．中药组小鼠体重均高于麻黄素组，肾重低于麻黄素组，肾小球直经明显小于麻黄素组，血清BUN、Cr含量均低于麻黄素组；麻黄素组小鼠肾皮质和髓质都有不同程度的损伤，中药组小鼠肾损伤有不同程度减轻和修复．表明中药复方液能有效减少麻黄素引起的组织细胞损伤，对麻黄素所致小鼠肾损伤有良好的保护作用．
탐토중약복방액대마황소치신조직손상적작용．마황소조자서용체증제량련속복강주사0.2 mL농도위2.0，3.0화4.0 g·L -1적마황소용액，중약조자서재주사마황소후분별관위0.2 mL농도위20.0，30.0화40.0 g·L -1적중약복방액，분별우급약후5 d ，10 d화15 d칭량검측자서적체중화신중；용비색법검측혈청BUN、Cr함량적변화；용광학현미경관찰자서신조직결구적변화병측량신소구직경적변화．결과현시마황소조소서체중균저우대조조，신중고우대조조，신소구직경명현대우대조조，혈청BUN、Cr함량균고우대조조．중약조소서체중균고우마황소조，신중저우마황소조，신소구직경명현소우마황소조，혈청BUN、Cr함량균저우마황소조；마황소조소서신피질화수질도유불동정도적손상，중약조소서신손상유불동정도감경화수복．표명중약복방액능유효감소마황소인기적조직세포손상，대마황소소치소서신손상유량호적보호작용．
To explore the poison effects of ephedrine and protective of Chinese medicine compound on filial mice injured by ephedrine , the ephedrine groups are intraperitoneal injected escalation doses 0.2 mL( 2.0 , 3.0 ,4.0 g · L -1 ) of ephedrine , and Chinese medicine group after injected ephedrine 1 h respectively intragastric with 0.2 mL the concentration of 20.0 ,30.0 and 40.0 g·L -1 of Chinese medicine compound . At 5 ,10 and 15 d respectively , body weight , kidney weight are determinded as well as content of BUN , Cr are examined by colorimetry . T he changes of the renal tissue structures are observerd by histological methods and diameter of glomeruli are measured . The results show that the ephedrine group body weight of mice are less than control group and kidney weight are higher than control group , the diameter of glomerular are higher than control group . The content of BUN , Cr of ephedrine group is higher than control group .But the Chinese medicine group , the body weight of mice is higher than the ephedrine group and kidney weight is less than ephedrine group , diameter of glomerular is less than ephedrine group , the content of serum BUN , Cr is less than ephedrine group . Kindey cortex and medulla of ephedrine group mice appear some different damnification . The damnification of Chinese medicine group mice kidney is lightened and renovated . Regular doses of ephedrine cause the histological damage of kidney . The Chinese medicine compound could reduce the tissue cell damage and protect kidney of mice from ephedrine damage effectively .